雌激素相关的子宫3':5'-环磷酸鸟苷水平升高。
Estrogen-related increases in uterine guanosine 3':5'-cyclic momophosphate levels.
作者信息
Kuehl F A, Ham E A, Zanetti M E, Sanford C H, Nicol S E, Goldberg N D
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):1866-70. doi: 10.1073/pnas.71.5.1866.
Abstract
Endogenous uterine cyclic GMP and cyclic AMP concentrations were monitored at each stage of the estrus cycle; cyclic GMP concentrations were found to be highest and cyclic AMP concentrations lowest during proestrus when plasma estrogen levels have been shown to be maximal. After administration of estradiol-17beta or diethylstilbestrol, the concentrations of uterine cyclic GMP in ovariectomized rats underwent a progressive and significant elevation and the levels of cyclic AMP declined significantly below control values when near maximal accumulation of tissue cyclic GMP was achieved. The increase in uterine cyclic GMP concentrations produced by estradiol benzoate administration was prevented when progesterone and the estrogen were co-administered. These results raise the possibility that an enhanced cellular accumulation of cyclic GMP may be involved in the expression of some of the actions of estrogen in uterine tissue.
摘要
在发情周期的每个阶段监测内源性子宫环鸟苷酸（cyclic GMP）和环腺苷酸（cyclic AMP）的浓度；当血浆雌激素水平已显示达到最大值时，发现发情前期环鸟苷酸浓度最高而环腺苷酸浓度最低。给予17β-雌二醇或己烯雌酚后，去卵巢大鼠子宫环鸟苷酸浓度进行性显著升高，当组织环鸟苷酸接近最大积累时，环腺苷酸水平显著下降至低于对照值。当同时给予孕酮和雌激素时，苯甲酸雌二醇给药所产生的子宫环鸟苷酸浓度升高被阻止。这些结果提示，环鸟苷酸细胞内积累增强可能参与雌激素在子宫组织中的某些作用的表达。
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