Taves E H, Wolfe B M
Department of Biochemistry, University of Western Ontario, London, Canada.
Lipids. 1989 Jul;24(7):669-72. doi: 10.1007/BF02535088.
The progestin, levonorgestrel, when administered to rats intramuscularly, significantly lowered both total and very low density lipoprotein triglyceride concentrations in the blood plasma by 35-40%. This effect was readily abolished by the simultaneous intramuscular administration of estradiol benzoate. Similarly, estradiol-17 beta overcame the inhibitory effects of levonorgestrel on the incorporation of [9,10-3H]palmitate into triglycerides of freshly isolated rat hepatocytes studied in vitro. However, estradiol alone significantly raised plasma triglycerides by two-fold in vivo. Estradiol also significantly enhanced (by 9%) the incorporation of [9,10-3H]palmitate into hepatocyte triglycerides. These results suggest that the effects of estradiol on triglyceride synthesis and concentration dominate over those of levonorgestrel in the rat.
向大鼠肌肉注射孕激素左炔诺孕酮后，血浆中总甘油三酯和极低密度脂蛋白甘油三酯的浓度显著降低了35%-40%。同时肌肉注射苯甲酸雌二醇可轻易消除这种作用。同样，在体外研究中，17β-雌二醇克服了左炔诺孕酮对新鲜分离的大鼠肝细胞中[9,10-3H]棕榈酸酯掺入甘油三酯的抑制作用。然而，单独使用雌二醇在体内可使血浆甘油三酯显著升高两倍。雌二醇还显著增强（9%）了[9,10-3H]棕榈酸酯掺入肝细胞甘油三酯的过程。这些结果表明，在大鼠中，雌二醇对甘油三酯合成和浓度的影响超过了左炔诺孕酮。
