Sladek C D, Joynt R J
Endocrinology. 1979 Mar;104(3):659-63. doi: 10.1210/endo-104-3-659.
Acetylcholine and nicotine stimulated vasopressin (VP) release from the organ-cultured rat hypothalamo-neurohypophyseal system (HNS). Nicotinic antagonists, hexamethonium, tetraethylammonium chloride, and trimethaphan blocked VP release in response to acetylcholine and nicotine. A muscarinic agonist, methacholine, was ineffective in eliciting VP release from HNS explants at a molar concentration equal to the maximally effective concentration of acetylcholine (10(-5) M). Atropine, a muscarinic antagonist, was an ineffective blocking agent for acetylcholine. These data indicate that the cholinergic receptor in the HNS explant is nicotinic rather than muscarinic in character.
乙酰胆碱和尼古丁可刺激器官培养的大鼠下丘脑 - 神经垂体系统（HNS）释放血管加压素（VP）。烟碱拮抗剂六甲铵、氯化四乙铵和阿方那特可阻断因乙酰胆碱和尼古丁引起的VP释放。毒蕈碱激动剂乙酰甲胆碱，在与乙酰胆碱最大有效浓度（10⁻⁵ M）相等的摩尔浓度下，从HNS外植体中引发VP释放无效。毒蕈碱拮抗剂阿托品，对乙酰胆碱而言是一种无效的阻断剂。这些数据表明，HNS外植体中的胆碱能受体在性质上是烟碱型而非毒蕈碱型。
