Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
作者信息
Russell D H, Looney W B, Kovacs C J, Hopkins H A, Marton L J, LeGendre S M, Morris H P
出版信息
Cancer Res. 1974 Sep;34(9):2382-5.
PMID:4367291
Abstract
摘要
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引用本文的文献
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Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.5-氟尿嘧啶与N1,N11-二乙基亚精胺联合使用可显著激活亚精胺/精胺N1-乙酰基转移酶的表达，消耗多胺，并协同诱导结肠癌细胞凋亡。
J Biol Chem. 2005 Feb 4;280(5):3295-304. doi: 10.1074/jbc.M409930200. Epub 2004 Nov 16.
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Urinary polyamine excretion by tumor-bearing and tumor-free mice exposed to cyclophosphamide, 5-fluorouracil and 6-mercaptopurine.荷瘤小鼠和无瘤小鼠在暴露于环磷酰胺、5-氟尿嘧啶和6-巯基嘌呤时的尿多胺排泄情况。
J Cancer Res Clin Oncol. 1986;111(2):141-8. doi: 10.1007/BF00400753.
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Spermidine level as a parameter in the treatment of patients with malignant melanoma.
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