Magyar P, Szathmáry I, Szobor A
Eur Neurol. 1979;18(1):59-65. doi: 10.1159/000115054.
25 myasthenia gravis-afflicted patients (14 crisis-endangered and 11 not endangered) were investigated with respect to their respiratory function and reaction of the respiratory parameters to Tensilon (edrophonium chloride). Results show that the vital capacity and the value of respiratory function parameters, measured under forced conditions, were partly significantly lower than those given as predicted values for healthy individuals. Maximal inspiratory flows indicated the greatest decrease. After intravenously administered Tensilon, the pathologically reduced maximal inspiratory flows increased. This positive effect of Tensilon can mark the alteration of the respiratory muscles and also the undertreatment of the patients. The observation that Tensilon may increase -- with some permanency -- the respiratory flow resistance and may decrease the maximal expiratory flow values, draws attention to the side effect (causing obstruction of the bronchi) of the drug, limiting its therapeutic use for patients in myasthenic crisis, especially in those complicated by obstructive lung disease.
对25例重症肌无力患者（14例处于危象期，11例未处于危象期）的呼吸功能以及呼吸参数对腾喜龙（氯化依酚氯铵）的反应进行了研究。结果显示，在强制条件下测量的肺活量和呼吸功能参数值，部分显著低于健康个体的预测值。最大吸气流量下降最为明显。静脉注射腾喜龙后，病理性降低的最大吸气流量增加。腾喜龙的这种积极作用可能标志着呼吸肌的改变以及患者治疗不足。观察发现，腾喜龙可能会在一定程度上持续增加呼吸流阻力，并可能降低最大呼气流量值，这引起了对该药物副作用（导致支气管阻塞）的关注，限制了其在重症肌无力危象患者，尤其是合并阻塞性肺病患者中的治疗应用。
