脑啡肽对平滑肌壁内抑制性非肾上腺素能神经反应的影响。
The effect of enkephalins on the intramural inhibitory non-adrenergic nerve responses of smooth muscle.
作者信息
Huizinga J D, den Hertog A
出版信息
Eur J Pharmacol. 1979 Mar 15;54(4):389-91. doi: 10.1016/0014-2999(79)90069-4.
The study concerned the effect of enkephalins and naloxone on the inhibitory non-adrenergic nerve responses of the taenia coli and the stomach smooth muscle cells of the guinea pig. Met-enkephalin, leu-enkephalin and D-ala-enkephalin (10(-8)10(-5)M) did not affect the muscle tension or membrane potential measured simultaneously using the sucrose-gap method. Naloxone (5x10(-8)--5x10(-6)M) relaxed the stomach strip, but did not modify the inhibitory junction potential. These results indicate that enkephalins are not involved in the nonadrenergic inhibitory nervous system, except possibly as neuromodulators at an interneuronal synaptic level.
该研究关注脑啡肽和纳洛酮对豚鼠结肠带和胃平滑肌细胞非肾上腺素能神经抑制反应的影响。甲硫氨酸脑啡肽、亮氨酸脑啡肽和D-丙氨酸脑啡肽（10⁻⁸ - 10⁻⁵M）不影响使用蔗糖间隙法同时测量的肌肉张力或膜电位。纳洛酮（5×10⁻⁸ - 5×10⁻⁶M）使胃条松弛，但不改变抑制性接头电位。这些结果表明，脑啡肽不参与非肾上腺素能抑制神经系统，可能仅作为中间神经元突触水平的神经调质。
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