Mishkel M A
Can Med Assoc J. 1974 Oct 19;111(8):775-80.
The status of cord blood screening of plasma lipids is reviewed, emphasizing the problems associated with the diagnosis of familial hyperlipoproteinemia (HLP), particularly type II (hyperbetalipoproteinemia), in the neonate. For 2937 neonates in this study the mean +/- standard deviation (SD) of plasma cholesterol was 70.3 +/- 16.9 mg/dl. The mean triglyceride level of 1805 neonates was 39.6 +/- 19.3 mg/dl. The mean level of beta-cholesterol in 240 neonates was 34.3 +/- 10.9 mg/dl and the correlation between total and beta-cholesterol was high (r=0.89). By convention, the upper limit of normal was defined as the mean + 2 SD, and these levels for total cholesterol, triglyceride and beta-cholesterol were 100, 80 and 55 mg/dl respectively. Only by careful follow-up of hyperlipidemic neonates can the incidence of HLP and the worth of early diagnosis be assessed.
本文综述了脐血脂质筛查的现状，重点强调了与新生儿家族性高脂蛋白血症（HLP）诊断相关的问题，尤其是II型（高β脂蛋白血症）。在本研究的2937例新生儿中，血浆胆固醇的均值±标准差（SD）为70.3±16.9mg/dl。1805例新生儿的甘油三酯平均水平为39.6±19.3mg/dl。240例新生儿的β-胆固醇平均水平为34.3±10.9mg/dl，总胆固醇与β-胆固醇之间的相关性较高（r=0.89）。按照惯例，正常上限定义为均值+2SD，总胆固醇、甘油三酯和β-胆固醇的这些水平分别为100、80和55mg/dl。只有通过对高脂血症新生儿进行仔细随访，才能评估HLP的发病率和早期诊断的价值。
