Kaplan W D, Trout W E
Genetics. 1974 Aug;77(4):721-39. doi: 10.1093/genetics/77.4.721.
The hyperkinetic mutants, Hk(1) and Hk(2), jump and fall over when an object moves near them. This behavior, the kinetogenic response, has been measured by the experimenter moving his hand above a vial containing a single fly and scoring the number of positive responses in fifty trials. The response is higher in Hk(1) than in Hk(2) and has remained so over a period of several years and in different genetic backgrounds. The Hk(1)/Hk(2) heterozygote also responds to movements, establishing the allelism of the two mutants.-When Sh(5), a shaker mutant at another locus on the X chromosome, is introduced into the same chromosome as Hk(1) or Hk(2), the response is reduced in proportion to the number of Sh(5) mutant genes added.-When Hk(1) or Hk(2) is heterozygous with a deficiency for the hyperkinetic region of the X chromosome, the expression is more abnormal than the respective Hk(1) or Hk(2) homozygote. This shows that the mutant genes are producing an altered gene product, or less of the normal, since one mutant gene by itself has a more abnormal expression than two. A tentative explanation has been offered for the observed mutant behaviors.
运动亢进突变体Hk(1)和Hk(2)在物体靠近它们时会跳跃并摔倒。这种行为，即动原反应，已由实验者通过在装有一只果蝇的小瓶上方移动他的手，并在五十次试验中对阳性反应的数量进行评分来测量。Hk(1)的反应比Hk(2)高，并且在几年的时间里以及在不同的遗传背景下一直如此。Hk(1)/Hk(2)杂合子也对运动有反应，确定了这两个突变体的等位性。当Sh(5)，一种位于X染色体另一位点的震颤突变体，与Hk(1)或Hk(2)引入到同一条染色体上时，反应会根据添加的Sh(5)突变基因的数量成比例降低。当Hk(1)或Hk(2)与X染色体运动亢进区域的缺失杂合时，其表达比各自的Hk(1)或Hk(2)纯合子更异常。这表明突变基因正在产生改变的基因产物，或者产生更少的正常产物，因为一个突变基因本身的表达比两个更异常。已经对观察到的突变行为提出了一个初步解释。
