Lukás E, Kotas P, Obrusník I
Br J Ind Med. 1974 Oct;31(4):288-91. doi: 10.1136/oem.31.4.288.
288-291. By means of neutron activation analysis the levels of zinc and copper in peripheral nerve tissue of two groups of rats with carbon-disulphide neuropathy were estimated. The neuropathy (diagnosed electromyographically) was evoked by inhalation of 3·6 mg CS/litre of air (variant 1) or 2·4 mg CS/litre of air (variant 2). Stationary Zn levels were found in control and exposed animals in both of the experimental variants, while the copper levels increased very significantly from 4·2 ± 0·3 ppm to 9·9 ± 1·7 ppm in experimantal variant 1 and from 2·4 ± 0·3 ppm to 5·6 ± 0·6 ppm in variant 2. The experiments suggest that changes in metal metabolism of peripheral nerve tissue deserve attention as one of the possible pathological links in the development of carbon-disulphide intoxication.
288 - 291。通过中子活化分析，对两组患有二硫化碳神经病变的大鼠外周神经组织中的锌和铜水平进行了估计。神经病变（通过肌电图诊断）是由吸入每升空气3.6毫克二硫化碳（变体1）或每升空气2.4毫克二硫化碳（变体2）引起的。在两个实验变体的对照动物和暴露动物中均发现锌水平稳定，而在实验变体1中，铜水平从4.2±0.3 ppm显著增加至9.9±1.7 ppm，在变体2中从2.4±0.3 ppm增加至5.6±0.6 ppm。实验表明，外周神经组织金属代谢的变化作为二硫化碳中毒发展中可能的病理环节之一值得关注。
