Opacka J, Wrońska-Nofer T
Toxicol Lett. 1982 Feb;10(2-3):139-44. doi: 10.1016/0378-4274(82)90065-0.
Some biochemical correlates of Wallerian degeneration of the peripheral nerve were compared in carbon disulphide (CS2) and acrylamide-induced neuropathies. Rats were exposed to CS2 at two concentrations (1.5 mg/l and 0.8 mg/l air). An increase in the activities of beta-glucuronidase and acid phosphatase, in the ratio of cholesterol esters to free cholesterol (E/F) and a decrease in phospholipids in the sciatic nerve of rats exposed to CS2 was found. The magnitude of these changes was related to the concentration of CS2 and the alterations were similar to those observed in the sciatic nerve of rats intoxicated with acrylamide.
比较了二硫化碳（CS2）和丙烯酰胺所致神经病中外周神经沃勒变性的一些生化关联。将大鼠暴露于两种浓度（1.5毫克/升和0.8毫克/升空气）的CS2中。发现暴露于CS2的大鼠坐骨神经中β-葡萄糖醛酸酶和酸性磷酸酶的活性增加、胆固醇酯与游离胆固醇的比例（E/F）增加以及磷脂减少。这些变化的程度与CS2的浓度有关，且这些改变与丙烯酰胺中毒大鼠坐骨神经中观察到的改变相似。
