多瘤假病毒感染小鼠细胞后假病毒DNA的降解
Degradation of pseudoviral DNA after infection of mouse cells with polyoma pseudovirions.
作者信息
Kashmiri S V, Aposhian H V
出版信息
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3834-8. doi: 10.1073/pnas.71.10.3834.
Abstract
When mouse cells are infected with [(3)H]-thymidine-labeled polyoma pseudovirions, as much as 11% of the input pseudoviral radioactivity is found in the recipient cell DNA. However, the radioactivity found in the recipient cell DNA virtually disappears when nonradioactive thymidine and deoxycytidine, or D-arabinosyl cytosine, are added to the medium. The radioactivity found in the recipient cell DNA appears to be the result of the breakdown of pseudoviral DNA to precursors of DNA and the utilization of these precursors for the synthesis of cell DNA.
摘要
当小鼠细胞被[³H] - 胸腺嘧啶标记的多瘤假病毒感染时，在受体细胞DNA中可发现高达11%的输入假病毒放射性。然而，当向培养基中添加非放射性胸腺嘧啶和脱氧胞苷或阿糖胞苷时，受体细胞DNA中发现的放射性几乎消失。受体细胞DNA中发现的放射性似乎是假病毒DNA分解为DNA前体并利用这些前体合成细胞DNA的结果。
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本文引用的文献
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INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS.多瘤病毒诱导细胞DNA合成
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The physical characteristics of polyoma virus. I. Two types of particle.多瘤病毒的物理特性。I. 两种类型的颗粒。
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Purification of polyoma virus.多瘤病毒的纯化
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Generalized transduction by bacteriophage P22 in Salmonella typhimurium. II. Mechanism of integration of transducing DNA.鼠伤寒沙门氏菌中噬菌体P22的广义转导。II. 转导DNA的整合机制。
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Generalized transduction by phage P22 in Salmonella typhimurium. I. Molecular origin of transducing DNA.噬菌体P22在鼠伤寒沙门氏菌中的广义转导。I. 转导DNA的分子起源
J Mol Biol. 1972 Nov 14;71(2):433-48. doi: 10.1016/0022-2836(72)90361-0.
8
The polyoma pseudovirion--its properties, production, and use in transferring DNA to mouse and human cells.多瘤假病毒颗粒——其特性、制备及其在将DNA转移至小鼠和人类细胞中的应用
Johns Hopkins Med J Suppl. 1973;2:35-45.
9
Polyoma pseudovirions. II. Influence of host cell on pseudovirus production.多瘤假病毒颗粒。II. 宿主细胞对假病毒产生的影响。
J Virol. 1973 Nov;12(5):1065-71. doi: 10.1128/JVI.12.5.1065-1071.1973.
10
Polyoma pseudovirions. I. Sequence of events in primary mouse embryo cells leading to pseudovirus production.多瘤假病毒颗粒。I. 原代小鼠胚胎细胞中导致假病毒产生的事件序列。
J Virol. 1972 Sep;10(3):340-6. doi: 10.1128/JVI.10.3.340-346.1972.
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