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敌草快和百草枯的生化效应。大鼠肾上腺皮质类固醇合成调控紊乱及对肝脏糖原利用控制的后续影响。

Biochemical effects of diquat and paraquat. Disturbance of the control of corticosteroid synthesis in rat adrenal and subsequent effects on the control of liver glycogen utilization.

作者信息

Rose M S, Crabtree H C, Fletcher K, Wyatt I

出版信息

Biochem J. 1974 Mar;138(3):437-43. doi: 10.1042/bj1380437.

DOI:10.1042/bj1380437
PMID:4372993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166229/
Abstract
  1. Administration of diquat (NN'-ethylene-2,2'-bipyridilium) or paraquat (NN'-dimethyl-4,4'-bipyridilium) prevents the normal depletion of liver glycogen in starved rats. 2. There is an increase in blood glucose, which returns to normal values after approx. 7h. 3. After administration of diquat or paraquat, plasma corticosteroids increase to very high concentrations and remain high for at least 24h, but plasma ACTH (adrenocorticotrophin) is only increased for 4h. 4. Adrenal cyclic AMP is considerably increased after administration of diquat and remains significantly higher than control values for at least 24h. 5. It is suggested that diquat and paraquat increase the response of the adrenal cortex to ACTH.
摘要
  1. 给饥饿的大鼠注射敌草快(NN'-亚乙基-2,2'-联吡啶鎓)或百草枯(NN'-二甲基-4,4'-联吡啶鎓)可防止肝脏糖原正常耗尽。2. 血糖升高,约7小时后恢复至正常水平。3. 注射敌草快或百草枯后,血浆皮质类固醇浓度升高至极高水平,并至少持续24小时保持高位,但血浆促肾上腺皮质激素(ACTH)仅在4小时内升高。4. 注射敌草快后,肾上腺环磷酸腺苷(cAMP)显著增加,并至少24小时显著高于对照值。5. 提示敌草快和百草枯增强了肾上腺皮质对ACTH的反应。

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Biochemical effects of diquat and paraquat. Disturbance of the control of corticosteroid synthesis in rat adrenal and subsequent effects on the control of liver glycogen utilization.敌草快和百草枯的生化效应。大鼠肾上腺皮质类固醇合成调控紊乱及对肝脏糖原利用控制的后续影响。
Biochem J. 1974 Mar;138(3):437-43. doi: 10.1042/bj1380437.
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Chem Biol Interact. 1977 Nov;19(2):143-60. doi: 10.1016/0009-2797(77)90027-8.

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本文引用的文献

1
[Effects of aldosterone on the glucide metabolism of the normal rat and of the adrenalectomized rat].[醛固酮对正常大鼠及肾上腺切除大鼠糖代谢的影响]
C R Seances Soc Biol Fil. 1961;155:790-2.
2
The activation of adrenal phosphorylase by the adrenocorticotropic hormone.促肾上腺皮质激素对肾上腺磷酸化酶的激活作用。
J Biol Chem. 1958 Nov;233(5):1220-2.
3
Measurement of free corticosteroids in rat plasma: physiological validation of a method.大鼠血浆中游离皮质类固醇的测定:一种方法的生理学验证
Endocrinology. 1958 Sep;63(3):349-58. doi: 10.1210/endo-63-3-349.
4
Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex.3',5'-环磷酸腺苷作为促肾上腺皮质激素作用于肾上腺皮质的细胞内介质。
J Biol Chem. 1967 Dec 10;242(23):5535-41.
5
Absorption and excretion of diquat and paraquat in rats.大鼠体内敌草快和百草枯的吸收与排泄
Br J Ind Med. 1966 Apr;23(2):133-6. doi: 10.1136/oem.23.2.133.
6
The toxicity of paraquat.百草枯的毒性。
Br J Ind Med. 1966 Apr;23(2):126-32. doi: 10.1136/oem.23.2.126.
7
Paraquat and related bipyridyls.百草枯及相关联吡啶类化合物。
Br Med Bull. 1969 Sep;25(3):245-9. doi: 10.1093/oxfordjournals.bmb.a070712.
8
Solvent extraction method for simultaneous determination of norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid in a single mouse brain.用于同时测定单只小鼠脑中去甲肾上腺素、多巴胺、5-羟色胺和5-羟基吲哚乙酸的溶剂萃取法
Anal Biochem. 1969 Aug;30(2):161-79. doi: 10.1016/0003-2697(69)90387-x.
9
Experimental paraquat poisoning: a histological and electron-optical study of the changes in the lung.实验性百草枯中毒:肺脏变化的组织学和电子光学研究
J Pathol. 1971 Feb;103(2):123-9. doi: 10.1002/path.1711030207.
10
Paraquat in the rabbit.兔体内的百草枯。
Br J Ind Med. 1971 Jan;28(1):67-71. doi: 10.1136/oem.28.1.67.