敌草快和百草枯的生化效应。大鼠肾上腺皮质类固醇合成调控紊乱及对肝脏糖原利用控制的后续影响。
Biochemical effects of diquat and paraquat. Disturbance of the control of corticosteroid synthesis in rat adrenal and subsequent effects on the control of liver glycogen utilization.
作者信息
Rose M S, Crabtree H C, Fletcher K, Wyatt I
出版信息
Biochem J. 1974 Mar;138(3):437-43. doi: 10.1042/bj1380437.
Abstract
- Administration of diquat (NN'-ethylene-2,2'-bipyridilium) or paraquat (NN'-dimethyl-4,4'-bipyridilium) prevents the normal depletion of liver glycogen in starved rats. 2. There is an increase in blood glucose, which returns to normal values after approx. 7h. 3. After administration of diquat or paraquat, plasma corticosteroids increase to very high concentrations and remain high for at least 24h, but plasma ACTH (adrenocorticotrophin) is only increased for 4h. 4. Adrenal cyclic AMP is considerably increased after administration of diquat and remains significantly higher than control values for at least 24h. 5. It is suggested that diquat and paraquat increase the response of the adrenal cortex to ACTH.
摘要
- 给饥饿的大鼠注射敌草快（NN'-亚乙基-2,2'-联吡啶鎓）或百草枯（NN'-二甲基-4,4'-联吡啶鎓）可防止肝脏糖原正常耗尽。2. 血糖升高，约7小时后恢复至正常水平。3. 注射敌草快或百草枯后，血浆皮质类固醇浓度升高至极高水平，并至少持续24小时保持高位，但血浆促肾上腺皮质激素（ACTH）仅在4小时内升高。4. 注射敌草快后，肾上腺环磷酸腺苷（cAMP）显著增加，并至少24小时显著高于对照值。5. 提示敌草快和百草枯增强了肾上腺皮质对ACTH的反应。
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