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兔体内的百草枯。

Paraquat in the rabbit.

作者信息

Butler C, Kleinerman J

出版信息

Br J Ind Med. 1971 Jan;28(1):67-71. doi: 10.1136/oem.28.1.67.

DOI:10.1136/oem.28.1.67
PMID:5543629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009193/
Abstract

Butler, C. II, and Kleinerman, J. (1971). 28, 67-71. Paraquat in the rabbit. Forty rabbits received paraquat intraperitoneally in total dosages of from 2 to 100 mg/kg and in one to five separate administrations. Nine animals which received 25 mg/kg or more died within four days of administration, and the remainder were killed at intervals of up to one month. The delayed pulmonary changes produced in man and other species by paraquat were not found in any animal, despite the fact that most animals were made ill by the chemical. Atrophy of the thymus and minimal renal tubular and focal peritoneal changes were present in animals found dead or killed soon after administration, but it was difficult to explain the cause of death.

摘要

巴特勒,C. II,和克莱纳曼,J.(1971年)。28卷,67 - 71页。兔体内的百草枯。40只兔子接受了腹腔注射百草枯,总剂量为2至100毫克/千克,分1至5次给药。9只接受25毫克/千克或更高剂量的动物在给药后4天内死亡,其余动物在长达1个月的间隔时间内被处死。尽管大多数动物因这种化学物质而生病,但在任何动物中都未发现百草枯在人类和其他物种中产生的延迟性肺部变化。给药后不久死亡或被处死的动物出现胸腺萎缩以及轻微的肾小管和局灶性腹膜变化,但很难解释死亡原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/5d16faf3c1ee/brjindmed00101-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/0bc0257519c8/brjindmed00101-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/f2ce28e33ad5/brjindmed00101-0073-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/5d16faf3c1ee/brjindmed00101-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/0bc0257519c8/brjindmed00101-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/f2ce28e33ad5/brjindmed00101-0073-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/1009193/5d16faf3c1ee/brjindmed00101-0074-a.jpg

相似文献

1
Paraquat in the rabbit.兔体内的百草枯。
Br J Ind Med. 1971 Jan;28(1):67-71. doi: 10.1136/oem.28.1.67.
2
Inhibition of paraquat accumulation in rabbit kidney cortex slices by ascorbic acid.
Res Commun Chem Pathol Pharmacol. 1989 Aug;65(2):245-8.
3
Alteration of the redox state of NADPH and glutathione in perfused rabbit lung by paraquat.百草枯对灌注兔肺中NADPH和谷胱甘肽氧化还原状态的影响。
Toxicol Ind Health. 1986 Dec;2(4):417-28. doi: 10.1177/074823378600200405.
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The influence of paraquat on the in vitro oxygen consumption of rabbit lung.百草枯对兔肺体外耗氧量的影响。
S Afr Med J. 1978 Jul 29;54(5):199-201.
5
[Hemoperfusion alleviated paraquat-induced kidney inflammation injury of rabbit].血液灌流减轻百草枯诱导的兔肾炎症损伤
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep;33(9):658-62.
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The effect of paraquat on the aerobic metabolism of rabbit alveolar macrophages and lung fibroblasts.百草枯对兔肺泡巨噬细胞和肺成纤维细胞有氧代谢的影响。
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Blowfly Larval Tissues as a Secondary Detector for Determining Paraquat-Related Death in Rabbit Carcass.
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8
Paraquat effect on the bioelectric parameters of the rabbit small intestine and its in vitro penetration.百草枯对兔小肠生物电参数及其体外渗透的影响。
Acta Physiol Pol. 1984 Jan-Feb;35(1):107-13.
9
The effect of oxygen and paraquat on the 14C-glucose oxidation of rabbit alveolar macrophages and lung slices.氧气和百草枯对兔肺泡巨噬细胞及肺切片14C-葡萄糖氧化的影响。
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引用本文的文献

1
Intrabronchial instillation of paraquat in rats: lung morphology and retention study.大鼠支气管内百草枯滴注:肺形态学与潴留研究
Br J Ind Med. 1981 Feb;38(1):42-8. doi: 10.1136/oem.38.1.42.
2
Oxidant injury of lung parenchymal cells.肺实质细胞的氧化损伤。
J Clin Invest. 1981 Nov;68(5):1277-88. doi: 10.1172/jci110374.
3
Paraquat: model for oxidant-initiated toxicity.百草枯:氧化应激引发毒性的模型。

本文引用的文献

1
Death from paraquat after subcutaneous injection.皮下注射百草枯后死亡。
Br Med J. 1967 Sep 16;3(5567):721. doi: 10.1136/bmj.3.5567.721.
2
Accidental poisoning by paraquat: Report of two cases in man.百草枯意外中毒:两例人体病例报告。
Br Med J. 1966 May 21;1(5498):1272-3. doi: 10.1136/bmj.1.5498.1272.
3
Absorption and excretion of diquat and paraquat in rats.大鼠体内敌草快和百草枯的吸收与排泄
Environ Health Perspect. 1984 Apr;55:37-46. doi: 10.1289/ehp.845537.
4
Ocular toxicity of paraquat.百草枯的眼毒性。
Bull Environ Contam Toxicol. 1973 Mar;9(3):163-8. doi: 10.1007/BF01684997.
5
Biochemical effects of diquat and paraquat. Disturbance of the control of corticosteroid synthesis in rat adrenal and subsequent effects on the control of liver glycogen utilization.敌草快和百草枯的生化效应。大鼠肾上腺皮质类固醇合成调控紊乱及对肝脏糖原利用控制的后续影响。
Biochem J. 1974 Mar;138(3):437-43. doi: 10.1042/bj1380437.
6
Recovery from paraquat pneumonitis.百草枯中毒性肺炎的康复
Br J Ind Med. 1985 Mar;42(3):178-83. doi: 10.1136/oem.42.3.178.
7
Paraquat lung injury in rabbits.兔百草枯肺损伤
Br J Ind Med. 1978 Aug;35(3):245-57. doi: 10.1136/oem.35.3.245.
Br J Ind Med. 1966 Apr;23(2):133-6. doi: 10.1136/oem.23.2.133.
4
The toxicity of paraquat.百草枯的毒性。
Br J Ind Med. 1966 Apr;23(2):126-32. doi: 10.1136/oem.23.2.126.
5
Paraquat poisoning in a pregnant woman.一名孕妇的百草枯中毒病例。
Br Med J. 1968 Sep 21;3(5620):722-3. doi: 10.1136/bmj.3.5620.722.
6
Paraquat poisoning treated by forced diuresis.采用强制利尿法治疗百草枯中毒。
Br Med J. 1968 Aug 3;3(5613):290-1. doi: 10.1136/bmj.3.5613.290.
7
Acute renal failure in case of Paraquat poisoning.百草枯中毒所致急性肾衰竭
Br Med J. 1968 Mar 23;1(5594):749-50. doi: 10.1136/bmj.1.5594.749.
8
The loss of pulmonary surfactant in paraquat poisoning: a model for the study of the respiratory distress syndrome.百草枯中毒时肺表面活性物质的丧失:呼吸窘迫综合征研究的一个模型
Br J Exp Pathol. 1967 Jun;48(3):366-9.
9
Paraquat poisoning--lung transplantation.百草枯中毒——肺移植
Br Med J. 1968 Sep 28;3(5621):759-63. doi: 10.1136/bmj.3.5621.759.
10
Death from paraquat in a child.
Lancet. 1968 Jan 20;1(7534):144. doi: 10.1016/s0140-6736(68)92754-2.