Burk R F, Barnhart J L
Gastroenterology. 1979 Jun;76(6):1363-7.
Iodipamide meglumine (Cholografin) has been implicated in several cases of liver injury in patients. The present study was designed to assess the hepatotoxic potential of this drug in rats. Iodipamide administered intraperitoneally or intravenously caused a characteristic type of necrosis which began in the midzonal area and spread to the centrilobular region. Only rats weighing 400 g or more developed necrosis when the dose administered was 2 mmol/kg. Rats weighing 200 g failed to develop liver necrosis even when given 3 mmol/kg. Selenium deficiency and pretreatment with 3-methylcholanthrene protected against liver necrosis due to iodipamide. Phenobarbital pretreatment provided little or no protection. Kidney tubular necrosis was also observed but occurred in young rats and in selenium-deficient rats which developed no liver necrosis. These results indicate that iodipamide is a hepatotoxin in rats. There are a number of factors, age being the most striking, that modify its hepatotoxicity.
碘番酸葡甲胺（胆影葡胺）已与多例患者肝损伤病例有关。本研究旨在评估该药物对大鼠的肝毒性潜力。腹腔注射或静脉注射碘番酸会引起一种特征性坏死类型，始于中区并蔓延至小叶中心区域。当给药剂量为2 mmol/kg时，只有体重400 g或以上的大鼠发生坏死。体重200 g的大鼠即使给予3 mmol/kg也未发生肝坏死。硒缺乏和用3-甲基胆蒽预处理可预防碘番酸引起的肝坏死。苯巴比妥预处理几乎没有或没有保护作用。还观察到肾小管坏死，但发生在未发生肝坏死的幼鼠和硒缺乏大鼠中。这些结果表明碘番酸是大鼠的肝毒素。有许多因素会改变其肝毒性，其中年龄最为显著。
