Motoki T, Ikeuchi M, Hirano M, Yatsuji Y, Murao S
Am J Gastroenterol. 1979 Jul;72(1):71-4.
There have been only two reports of severe hepatotoxic reaction caused by meglumine iodipamide. Lately we experienced such a reaction in an 66-year old female with chronic intrahepatic cholestasis. After drip infusion cholangiography was performed by infusing 40 ml. of 50% meglumine iodipamide (Biligrafin) intravenously, the patient developed nausea and abdominal pain. Her serum transaminase rose to more than 2,000 K-A units on the third day and gradually returned to normal by the 18th day. The macrophage migration inhibition test of her blood was positive for meglumine iodipamide. Accordingly some delayed type of hypersensitivity in the above reaction could be considered. When a larger amount than a recommended dose of meglumine iodipamide is infused in cholangiography, a severe hepatotoxic reaction might be induced, especially in icteric cases.
关于碘番酸葡甲胺引起严重肝毒性反应的报道仅有两例。最近，我们在一名患有慢性肝内胆汁淤积的66岁女性患者身上遇到了这样的反应。静脉滴注40毫升50%碘番酸葡甲胺（胆影葡胺）进行胆管造影后，患者出现恶心和腹痛。第三天她的血清转氨酶升至2000 K-A单位以上，并在第18天逐渐恢复正常。她血液的巨噬细胞移动抑制试验对碘番酸葡甲胺呈阳性。因此，可以认为上述反应存在某种迟发型超敏反应。当在胆管造影中注入超过推荐剂量的碘番酸葡甲胺时，可能会诱发严重的肝毒性反应，尤其是在黄疸病例中。
