猕猴疱疹病毒（B病毒）的异质性及疱疹病毒组中的一些抗原关系。
Heterogeneity in Herpes simiae (B virus) and some antigenic relationships in the herpes group.
作者信息
Vizoso A D
出版信息
Br J Exp Pathol. 1974 Oct;55(5):471-7.
(B virus) grown in rabbit brain was passaged 9 times through the brains of suckling hamsters and treated with antiserum against virus at each passage. Its properties were compared with a control line passaged in the absence of antiserum. When measured in terms of the ratio of infectivity for suckling hamsters to infectivity for rabbits (both inoculated intracerebrally), the control line of virus showed a greater increase in infectivity for suckling hamsters than did the antibody selected line. The latter, dose for dose, killed suckling hamsters more quickly. Whereas the parent and control lines produced several kinds of cytopathic effect in cell cultures, the antibody selected line induced predominantly the formation of syncytia. Cross neutralization tests with antisera against various herpes viruses revealed that the antibody selected line differed antigenically from the control line. In these tests, serum from a patient who died of herpes encephalitis resembled antiserum against B virus rather than antiserum against virus.
在兔脑内培养的B病毒通过乳鼠脑传代9次，每次传代时都用抗该病毒的抗血清处理。将其特性与在无抗血清情况下传代的对照株进行比较。当以乳鼠的感染性与兔的感染性之比（两者均经脑内接种）来衡量时，病毒对照株对乳鼠的感染性增加幅度大于抗体选择株。后者在相同剂量下能更快地杀死乳鼠。亲本株和对照株在细胞培养中产生几种细胞病变效应，而抗体选择株主要诱导多核巨细胞形成。用针对各种疱疹病毒的抗血清进行的交叉中和试验表明，抗体选择株在抗原性上与对照株不同。在这些试验中，死于疱疹性脑炎患者的血清更类似于抗B病毒血清，而不是抗该病毒血清。
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