Kaczmarski F, Dabroś W
Folia Histochem Cytochem (Krakow). 1979;17(1):85-91.
A comparative morphological analysis of the effects of vincristine on particular types of muscle fibres of the eye and selected trunk muscles of the mouse was performed. Great resistance of the mouse organism to the action of sublethal doses of vincristine has been found. Degenerative changes of great intensity (atrophy of myofibrils, disturbances of the Z line) and the appearance of new changes, not mentioned hitherto among the vincristine myopathies (megamitochondria, intermembranous inclusions, glycogen in mitochondria and very large vacuoles) were observed in the trunk muscles of mice. The eye muscles are seem to be more resistant to the action of vincristine. The intensity of changes in the eye muscles was connected with the types of muscle fibres. Red fibres, rich in mitochondria, underwent relatively greatest changes, whereas the smallest changes were found in tonic fibres, poor in mitochondria and sarcotubular system, i.e. these structures from which spheromembranous bodies, most characteristic of the pathogenic effects of vincristine arise.
对长春新碱对小鼠眼部特定类型肌纤维和选定躯干肌肉的影响进行了比较形态学分析。已发现小鼠机体对亚致死剂量长春新碱的作用具有很强的抵抗力。在小鼠的躯干肌肉中观察到高强度的退行性变化（肌原纤维萎缩、Z线紊乱）以及新变化的出现，这些变化在以往的长春新碱肌病中未曾提及（巨型线粒体、膜间包涵体、线粒体中的糖原和非常大的液泡）。眼肌似乎对长春新碱的作用更具抵抗力。眼肌变化的强度与肌纤维类型有关。富含线粒体的红色纤维发生的变化相对最大，而线粒体和肌管系统较少的紧张性纤维发生的变化最小，即长春新碱致病作用最具特征性的球膜体就是从这些结构产生的。
