Dabroś W, Ochalska B
Folia Histochem Cytochem (Krakow). 1979;17(3):259-66.
A morphological analysis of the effect of vincristine (VCR) on the cardiac muscle and smooth muscles of blood-vessels and alimentary canal of mice has been carried out. These animals show a high resistance to sublethal doses of VCR. The changes in the cardiac muscle involve mitochondria. The widening of the space between the intercalated discs is seen and accompanied by the occurrence of spheromembranous bodies (SMB) in it. The only alteration typical of the effect of VCR in the smooth muscles is the presence of SMB inside the mitochondria. The number and extent of changes observed increased in course of experiment.
已对长春新碱（VCR）对小鼠心肌以及血管和消化道平滑肌的影响进行了形态学分析。这些动物对亚致死剂量的VCR表现出高度抗性。心肌的变化涉及线粒体。可见闰盘之间的间隙增宽，并伴有其中球形膜性小体（SMB）的出现。VCR对平滑肌作用的唯一典型改变是线粒体内部存在SMB。在实验过程中观察到的变化数量和程度有所增加。
