Malák G, Tapolcsányi L
Oncology. 1974;30(4):278-93. doi: 10.1159/000224967.
The analysis of 73 cases revealed Paget's disease of the nipple, known as a precancerous state, to be a special form of the intraductal mammary cancers. In the majority of the cases, apart from a superficial exulceration malignant transformation in the glandular substance is present. Thus, the treatment schedules have to be similar to those of other mammary cancers; in cases localized to the nipple, simple mastectomy with axillary block dissection, is suggested; in cases with tumors of the glandular substance, radical mastectomy according to Halsted is suggested. The frequent negligency is partly a result of an earlier attitude of the physicians being too conservative with therapeutic procedures.
对73例病例的分析显示，乳头佩吉特病，一种被认为是癌前状态的疾病，是乳腺导管内癌的一种特殊形式。在大多数病例中，除了表面溃疡外，腺体实质内还存在恶性转化。因此，治疗方案必须与其他乳腺癌相似；对于局限于乳头的病例，建议行单纯乳房切除术加腋窝淋巴结清扫术；对于腺体实质有肿瘤的病例，建议行Halsted根治性乳房切除术。这种频繁的疏忽部分是由于医生早期对治疗程序过于保守的态度所致。
