[Oncogen infectious nucleoprotein and herpes virus hominis type 2 in stages of cervical cancer. Investigatious by indirect immunofluorescens].

Using HVH 2 antisera of rabbit (titre 1:256, dilution 1:10), antologous serum of cervix carcinoma patients (dilution 1:1 to 1:5) and allogenic serum of cervix carcinoma patients without HVH 2 antibodies (dilution 1:1 to 1:5), tumour material obtained from various cancerization stages of cervix carcinoma in 50 cases was incubated following trypsination to single cells with fluoresceine isothiocyanate labelled anti-human globulin and anti-rabbit globulin. Apart from HVH antigens significantly differing in quantity from one stage to the other as detected by immune fluorescence methods, a perinuclear distinct antigen, unrelated to HVH antigens, has also been demonstrated. The last mentioned one might be a specific tumour antigen or an embryonic antigen. The occurrence of an indirectly or directly HVH 2 inducing antigen is considered less probable.