Levo Y, Pick A I, Cohen I, Atsmon A
Haemostasis. 1974;3(3):167-70. doi: 10.1159/000214052.
A patient with a fulminant clinical course of disseminated intravascular coagulation (DIC) is described. The DIC was first manifested by neurological symptoms and later dominated by hemorrhagic phenomena. Bleeding manifestations were not controlled by treatment with heparin, later supplemented with epsilon-amino-caproic acid and fresh blood. The patient's condition precluded the performance of extensive diagnostic procedures. On the assumption that malignancy was the underlying disease, cyclophosphamide and hydrocortisone were administered. In spite of intensive treatment the patient died. Autopsy revealed mesenteric lymph node metastases of a mucinous adenocarcinoma, probably originating in the colon. It is emphasized that in some patients with malignant disease, acute DIC is the presenting and the predominant symptom. In such patients the hemorrhagic manifestations may not be controlled unless the underlying neoplastic disease is detected and treated.
本文描述了一名患有暴发性弥散性血管内凝血（DIC）临床过程的患者。DIC最初表现为神经症状，随后以出血现象为主。肝素治疗未能控制出血表现，随后补充了ε-氨基己酸和新鲜血液。患者的病情不允许进行广泛的诊断程序。基于恶性肿瘤为潜在疾病的假设，给予了环磷酰胺和氢化可的松治疗。尽管进行了强化治疗，患者仍死亡。尸检显示为黏液腺癌的肠系膜淋巴结转移，可能起源于结肠。需要强调的是，在一些患有恶性疾病的患者中，急性DIC是首发且主要的症状。在这类患者中，除非检测并治疗潜在的肿瘤疾病，否则出血表现可能无法得到控制。
