Barbosa C A, Krieger H
Hum Hered. 1979;29(2):106-10. doi: 10.1159/000153025.
The possible role of genetic mechanisms, as revealed by inbreeding depression and pleiotropic effects of the ABO, Es D and CA II loci, on blood pressures, pulse rate and hematocrit, was studied in a sample of 7,642 migrant Brazilian individuals of rural origin. It was not possible to confirm previous claims of the effects of ABO blood groups system and inbreeding on diastolic blood pressure. On the other hand, a significant inbreeding depression on pulse rate of about 1.23 bmp/10% F, among adult individuals, was revealed. The observed significant effects of several markers on hemodynamic variables, due to its number, were attributed to chance.
通过对7642名来自巴西农村的移民个体进行研究，探讨了近亲繁殖衰退以及ABO、Es D和CA II基因座的多效性效应所揭示的遗传机制在血压、脉搏率和血细胞比容方面可能发挥的作用。无法证实先前关于ABO血型系统和近亲繁殖对舒张压影响的说法。另一方面，研究发现成年个体中脉搏率存在显著的近亲繁殖衰退，约为1.23次/分钟/10%近亲系数。由于多个标记对血流动力学变量产生的显著影响数量较多，因此被认为是偶然因素所致。
