细菌脂多糖（内毒素）激活哈格曼因子（因子XII）的直接证据。
Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins).
作者信息
Morrison D C, Cochrane C G
出版信息
J Exp Med. 1974 Sep 1;140(3):797-811. doi: 10.1084/jem.140.3.797.
Abstract
Purified precursor Hageman factor has been demonstrated to bind to soluble bacterial lipopolysaccharide (LPS, endotoxin) isolated from Escherichia coli 0111:B4, and this complex has been shown to have the capacity to convert prekallikrein to its active form. In addition, LPS-activated Hageman factor substantially reduces clotting times in XII-deficient plasma. The capacity to activate Hageman factor has been demonstrated to reside in the lipid A region of the LPS molecule. Activation of Hageman factor by LPS contrasts with fluid-phase activation (e.g., by kallikrein or trypsin) in that no cleavage to lower molecular weight fragments occurs. High concentrations of LPS inhibit the activity of Hageman factor, probably by a direct LPS-Hageman factor interaction.
摘要
纯化的前激肽释放酶原已被证明能与从大肠杆菌0111:B4中分离出的可溶性细菌脂多糖（LPS，内毒素）结合，并且这种复合物已被证明有能力将前激肽释放酶转化为其活性形式。此外，LPS激活的前激肽释放酶原能显著缩短缺乏因子XII的血浆的凝血时间。已证明激活前激肽释放酶原的能力存在于LPS分子的脂质A区域。LPS对前激肽释放酶原的激活与液相激活（如由激肽释放酶或胰蛋白酶激活）不同，因为不会发生切割成低分子量片段的情况。高浓度的LPS可能通过LPS与前激肽释放酶原的直接相互作用来抑制前激肽释放酶原的活性。
相似文献
1
Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins).
J Exp Med. 1974 Sep 1;140(3):797-811. doi: 10.1084/jem.140.3.797.
2
The first component of the kinin-forming system in human and rabbit plasma. Its relationship to clotting factor XII (Hageman Factor).
J Exp Med. 1971 Oct 1;134(4):986-1004. doi: 10.1084/jem.134.4.986.
3
Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein.
J Exp Med. 1973 Dec 1;138(6):1564-83. doi: 10.1084/jem.138.6.1564.
4
Initiation of plasma prorenin activation by Hageman factor-dependent conversion of plasma prekallikrein to kallikrein.
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5914-8. doi: 10.1073/pnas.76.11.5914.
5
The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen.
J Clin Invest. 1977 Jun;59(6):1167-75. doi: 10.1172/JCI108741.
6
Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor.
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2554-8. doi: 10.1073/pnas.73.8.2554.
7
Studies on prekallikrein of bovine plasma. II. Activation of prekallikrein with proteinases and properties of kallikrein activated by bovine Hageman factor.
J Biochem. 1980 Jan;87(1):23-34. doi: 10.1093/oxfordjournals.jbchem.a132730.
8
Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII).
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1998-2002. doi: 10.1073/pnas.75.4.1998.
9
Interactions among Hageman factor, plasma prekallikrein, high molecular weight kininogen, and plasma thromboplastin antecedent.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):958-61. doi: 10.1073/pnas.76.2.958.
10
Fletcher factor deficiency. A diminished rate of Hageman factor activation caused by absence of prekallikrein with abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation.
J Clin Invest. 1974 Feb;53(2):622-33. doi: 10.1172/JCI107597.
引用本文的文献
1
Bradykinin B1 receptor signaling triggers complement activation on endothelial cells.
Front Immunol. 2025 Feb 7;16:1527065. doi: 10.3389/fimmu.2025.1527065. eCollection 2025.
2
Lipopolysaccharide supramolecular organization regulates the activation of coagulation factor XII.
Biochim Biophys Acta Biomembr. 2025 Mar;1867(3):184415. doi: 10.1016/j.bbamem.2025.184415. Epub 2025 Feb 6.
3
Alzheimer's Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy.
Cells. 2024 Dec 10;13(24):2039. doi: 10.3390/cells13242039.
4
The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation.
J Biol Chem. 2025 Jan;301(1):108110. doi: 10.1016/j.jbc.2024.108110. Epub 2024 Dec 18.
5
6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors.
Cardiovasc Hematol Agents Med Chem. 2023;21(3):243-249. doi: 10.2174/1871525721666230126114224.
6
Inflammation, Infection and Venous Thromboembolism.
Circ Res. 2021 Jun 11;128(12):2017-2036. doi: 10.1161/CIRCRESAHA.121.318225. Epub 2021 Jun 10.
7
Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema.
Clin Rev Allergy Immunol. 2021 Jun;60(3):348-356. doi: 10.1007/s12016-021-08837-6. Epub 2021 May 6.
8
Kallikrein Cleaves C3 and Activates Complement.
J Innate Immun. 2018;10(2):94-105. doi: 10.1159/000484257. Epub 2017 Dec 14.
9
An essential role of high-molecular-weight kininogen in endotoxemia.
J Exp Med. 2017 Sep 4;214(9):2649-2670. doi: 10.1084/jem.20161900. Epub 2017 Aug 9.
10
Processing of Factor XII during Inflammatory Reactions.
Front Med (Lausanne). 2016 Nov 4;3:52. doi: 10.3389/fmed.2016.00052. eCollection 2016.
本文引用的文献
1
The Origin of the Epithelioid Cell in Experimental Tuberculosis of the Cornea.
Am J Pathol. 1933 May;9(3):337-346.9.
2
ACTINOMYCIN SENSITIVITY IN ESCHERICHIA COLI PRODUCED BY EDTA.
Biochem Biophys Res Commun. 1965 Jan 4;18:13-7. doi: 10.1016/0006-291x(65)90874-0.
3
ACTIVATION OF HAGEMAN FACTOR (FACTOR XII) BY LONG-CHAIN SATURATED FATTY ACIDS.
Thromb Diath Haemorrh. 1963 Jul 15;33:346-53.
4
THE CLOT-PROMOTING EFFECT OF SOAPS OF LONG-CHAIN SATURATED FATTY ACIDS.
J Clin Invest. 1963 Oct;42(10):1569-77. doi: 10.1172/JCI104842.
5
Activation of Hagemen Factor by saturated fatty acids.
Aust J Exp Biol Med Sci. 1962 Dec;40:505-13. doi: 10.1038/icb.1962.54.
6
Estimation of 3-deoxy sugars by means of the malonaldehyde-thiobarbituric acid reaction.
Nature. 1960 Apr 9;186:155-6. doi: 10.1038/186155a0.
7
The role of Hageman factor in the initiation of blood coagulation.
Br J Haematol. 1959 Apr;5(2):203-11. doi: 10.1111/j.1365-2141.1959.tb04026.x.
8
A new method for the extraction of R lipopolysaccharides.
Eur J Biochem. 1969 Jun;9(2):245-9. doi: 10.1111/j.1432-1033.1969.tb00601.x.
9
Endotoxin-induced intravascular clotting: the need for granulocytes.
Thromb Diath Haemorrh. 1968 Dec 31;20(3):430-43.
10
Plasma kallikrein and Hageman factor in Gram-negative bacteremia.
Ann Intern Med. 1970 Oct;73(4):545-51. doi: 10.7326/0003-4819-73-4-545.
Zotero 插件