Mitchell G F, Clarke A E
Int Arch Allergy Appl Immunol. 1979;58(4):391-401. doi: 10.1159/000232218.
Concanavalin A (Con A) is a potent allergen in certain strains of mice and in particularly the H-2Kk mice, A/J, CBA/H, and C3H/He. Using a dose of 100 microgram, the subcutaneous route of injection was the most effective means of inducing high, persistent titers of T cell-dependent circulating anti-Con A reagins without the addition of the classical IgE adjuvants, aluminium hydroxide and Bordetella pertussis vaccine. Haptenated Con A induced reagins with antihapten specificity. In the discussion, one possible contributing factor in Con A allergenicity in genetically responder strains of mice is emphasised, namely, persistence in subcutaneous injection sites.
刀豆球蛋白A（Con A）在某些品系的小鼠中是一种强效变应原，尤其是在H-2Kk小鼠、A/J、CBA/H和C3H/He小鼠中。使用100微克的剂量，皮下注射途径是诱导高滴度、持续的T细胞依赖性循环抗Con A反应素的最有效方法，无需添加传统的IgE佐剂氢氧化铝和百日咳博德特氏菌疫苗。半抗原化的Con A诱导具有抗半抗原特异性的反应素。在讨论中，强调了在基因反应性小鼠品系中Con A变应原性的一个可能促成因素，即在皮下注射部位的持久性。
