Schumacher M J, Mitchell G F
Int Arch Allergy Appl Immunol. 1980;62(4):382-8. doi: 10.1159/000232540.
Optimal conditions were established for induction of reaginic antibodies to Lolium perenne pollen allergens in mice by intranasal dosing of allergens with Bordetella pertussis vaccine. This antibody response could be inhibited by pretreatment of the mice by nasal administration of 100 microgram of glutaraldehyde-modified L. perenne allergens 9 times in 3 weeks before priming, whereas native allergens, in doses of 5 microgram, did not inhibit an IgE response to subsequent priming. It was not possible to suppress an ongoing reaginic antibody response by intranasal treatment with either native allergens, or glutaraldehyde-modified allergens. Relevance to immunoprophylaxis of allergic disease is discussed.
通过向小鼠鼻内注射黑麦草花粉过敏原和百日咳疫苗，确定了诱导小鼠产生针对黑麦草花粉过敏原的反应素抗体的最佳条件。在致敏前3周内，通过鼻内给予100微克戊二醛修饰的黑麦草过敏原9次对小鼠进行预处理，可抑制这种抗体反应，而5微克剂量的天然过敏原则不会抑制对后续致敏的IgE反应。用天然过敏原或戊二醛修饰的过敏原进行鼻内治疗，均无法抑制正在进行的反应素抗体反应。文中讨论了其与过敏性疾病免疫预防的相关性。
