Stevenson N R, Day S E, Sitren H
Int J Chronobiol. 1979;6(1):1-12.
Circadian rhythmicity has been reported in various small intestinal digestive-absorptive functions and in the mitotic activity of intestinal crypt cells. These functional activity rhythms and perhaps the mitotic rhythms are cued by the feeding schedule. We now report that circadian rhythms also occurred in both the villus height and cell number in rats maintained on morning or afternoon feeding schedules for 7 days. Villus width was constant. In afternoon-fed rats both villus height and cell number were 50% greater just before feeding than 12 h later. The amplitudes of the two rhythms in the morning fed rats were decreased, the general shape of the cycles were changed and the average number of cells was increased. These changes between morning and afternoon feeding are attributed to incomplete phase shifting due to an insufficient adaptation span for the morning fed rats. We conclude that circadian rhythms occurring in villus height and cell number are affected by the feeding schedule. Similarities to some previously reported functional rhythms suggest that fluctuations in cell number and/or villus length might be related to the functional changes.
据报道，各种小肠消化吸收功能以及肠隐窝细胞的有丝分裂活动都存在昼夜节律。这些功能活动节律以及或许还有有丝分裂节律是由进食时间表所提示的。我们现在报告，在按上午或下午进食时间表喂养7天的大鼠中，绒毛高度和细胞数量也出现了昼夜节律。绒毛宽度保持恒定。在下午进食的大鼠中，就在进食前，绒毛高度和细胞数量比12小时后高出50%。上午进食的大鼠中这两种节律的幅度减小，周期的总体形状改变，细胞平均数量增加。上午和下午进食之间的这些变化归因于上午进食的大鼠适应期不足导致的不完全相位转移。我们得出结论，绒毛高度和细胞数量中出现的昼夜节律受进食时间表影响。与一些先前报道的功能节律的相似性表明，细胞数量和/或绒毛长度的波动可能与功能变化有关。
