Hales C A, Westphal D M
J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):529-33. doi: 10.1152/jappl.1979.46.3.529.
The influence of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on regional alveolar hypoxic vasconstriction and on global hypoxic pulmonary vasoconstriction was investigated. In eight dogs a double-lumened endotracheal tube allowed ventilation of one lung with nitrogen as an alveolar hypoxic challenge while ventilation of the other lung with 100% O2 maintained adequate systemic oxygenation. Distribution of perfusion to the two lungs was determined with 133Xe and external counters. Mean perfusion to the test lung was 50.9 +/- 4.9% of total lung perfusion on room air and decreased by 32.4% (P smaller than 0.01) during alveolar hypoxia. Following 6-OHDA the test lung continued to reduce perfusion during alveolar hypoxia by 27.3%. In five dogs global hypoxia induced a 106% increase in pulmonary vascular resistance (PVR) prior to 6-OHDA and a 90% increase in PVR after 6-OHDA. After 6-OHDA no rise in PRV or systemic blood pressure occurred in response to tyramine, confirming effective sympathectomy by the 6-OHDA. Thus, sympathectomy with 6-OHDA failed to substantially block regional alveolar hypoxic vasoconstriction or global hypoxic pulmonary vasconstriction.
研究了用6-羟基多巴胺（6-OHDA）进行化学性交感神经切除术对局部肺泡低氧性血管收缩和整体低氧性肺血管收缩的影响。在8只狗中，使用双腔气管导管，用氮气对一侧肺进行通气，作为肺泡低氧刺激，而另一侧肺用100%氧气通气以维持足够的全身氧合。用133Xe和外部计数器测定两肺的灌注分布。在室内空气中，试验肺的平均灌注占总肺灌注的50.9±4.9%，在肺泡低氧期间减少了32.4%（P<0.01）。给予6-OHDA后，试验肺在肺泡低氧期间继续减少灌注27.3%。在5只狗中，整体低氧在给予6-OHDA之前使肺血管阻力（PVR）增加106%，给予6-OHDA之后使PVR增加90%。给予6-OHDA后，对酪胺无PRV或全身血压升高反应，证实6-OHDA有效切除了交感神经。因此，用6-OHDA进行交感神经切除术未能实质性地阻断局部肺泡低氧性血管收缩或整体低氧性肺血管收缩。
