Tucker A
Cardiovasc Res. 1979 Aug;13(8):469-76. doi: 10.1093/cvr/13.8.469.
Mongrel dogs were anesthetised and exposed to acute hypoxia (8% or 10% O2 for 10 min) before and again either 2 or 12 days after 6-hydroxydopamine (6-OHDA, 80 mg . kg-1) pretreatment. Under normoxic conditions, systemic arterial pressure and systemic vascular resistance were reduced 2 days post 6-OHDA, but only systemic resistance was reduced 12 days post 6-OHDA. Pulmonary vascular haemodynamics were unchanged by 6-OHDA under normoxic conditions. No changes in the cardiac output, pulmonary, and systemic haemodynamic or ventilatory responses to hypoxia were observed 2 days post 6-OHDA, although the heart rate response was reduced. Similarly, 12 days post 6-OHDA, reponses to hypoxia were unchanged except for a reduced systemic pressor response. A significant transient fall in systemic arterial pressure was observed at the start of the hypoxic exposure 2 days post 6-OHDA. The ventilatory responses to hypoxia appeared to be influenced very little by the sympathetic nervous system. The results indicate that pulmonary vascular resistance is under little sympathetic influence, and that hypoxic pulmonary vasoconstriction is not mediated by the sympathetic nervous system.
杂种犬在接受6-羟基多巴胺（6-OHDA，80mg·kg-1）预处理之前以及预处理后2天或12天再次接受急性低氧（8%或10%氧气，持续10分钟）处理时被麻醉。在常氧条件下，6-OHDA处理后2天，体循环动脉压和体循环血管阻力降低，但6-OHDA处理后12天只有体循环阻力降低。在常氧条件下，6-OHDA对肺血管血流动力学无影响。6-OHDA处理后2天，尽管心率反应降低，但未观察到心输出量、肺和体循环血流动力学或对低氧的通气反应有变化。同样，6-OHDA处理后12天，除体循环升压反应降低外，对低氧的反应未发生变化。6-OHDA处理后2天，在低氧暴露开始时观察到体循环动脉压有显著短暂下降。通气对低氧的反应似乎很少受交感神经系统影响。结果表明，肺血管阻力很少受交感神经影响，并且低氧性肺血管收缩不是由交感神经系统介导的。
