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戊酸倍他米松:在人体学习、记忆和能力测试中无促进作用。

Magnesium pemolone: lack of facilitation in human learning, memory, and performance tests.

作者信息

Smith R G

出版信息

Science. 1967 Feb 3;155(3762):603-5. doi: 10.1126/science.155.3762.603.

DOI:10.1126/science.155.3762.603
PMID:4380966
Abstract

Either a placebo or 25 or 37.5 milligrams of magnesium pemoline was administered on a doubleblind basis to three intelligencematched groups of normal, adult males. Learning and 24-hour retention tests included verbal learning, motor learning, and classical conditioning. Short-term memory tests were administered through both the visual and auditory modalities. Arm-hand steadiness and visual reaction time performance tests were included. The only measures revealing significant group differences showed the performance of subjects given pemoline was inferior to that of subjects given a placebo.

摘要

在双盲的基础上,给三组智力匹配的正常成年男性分别服用安慰剂、25毫克或37.5毫克的匹莫林。学习和24小时记忆测试包括言语学习、运动学习和经典条件反射。短期记忆测试通过视觉和听觉两种方式进行。还包括手臂手部稳定性和视觉反应时间性能测试。唯一显示出显著组间差异的测量结果表明,服用匹莫林的受试者的表现不如服用安慰剂的受试者。

相似文献

1
Magnesium pemolone: lack of facilitation in human learning, memory, and performance tests.戊酸倍他米松:在人体学习、记忆和能力测试中无促进作用。
Science. 1967 Feb 3;155(3762):603-5. doi: 10.1126/science.155.3762.603.
2
Tests of learning and memory with Cylert.使用中枢神经兴奋剂进行学习和记忆测试。
Psychopharmacologia. 1967;10(5):445-51. doi: 10.1007/BF00403986.
3
[Learning and memory in the operatively conditioned rat after administration of Mg-pemoline].
Boll Soc Ital Biol Sper. 1966 Nov 30;42(22):1594-6.
4
Learning and memory enhancement by pemoline and magnesium hydroxide (PMH).匹莫林与氢氧化镁(PMH)对学习和记忆的增强作用
Recent Adv Biol Psychiatry. 1968;10:102-20. doi: 10.1007/978-1-4684-9072-5_9.
5
Pemoline and magnesium hydroxide versus pemoline: enhancement of learning and memory of a conditioned avoidance response in rats.
J Pharm Sci. 1967 Feb;56(2):290-1. doi: 10.1002/jps.2600560235.
6
Effects of magnesium pemoline and dextroamphetamine on human learning.
Science. 1967 Feb 17;155(3764):849-51. doi: 10.1126/science.155.3764.849.
7
Performance tests of amnesic patients with cylert.使用哌醋甲酯对遗忘症患者进行的性能测试。
J Nerv Ment Dis. 1967 May;144(5):421-9. doi: 10.1097/00005053-196705000-00010.
8
Magnesium pemoline and behavior.匹莫林与行为
Science. 1966 Aug 19;153(3738):902. doi: 10.1126/science.153.3738.902.
9
Magnesium pemoline: effect on avoidance conditioning in rats.匹莫林镁:对大鼠回避条件反射的影响。
Science. 1967 Mar 10;155(3767):1281-2. doi: 10.1126/science.155.3767.1281.
10
Magnesium pemoline: enhancement of memory after electroconvulsive shock in rats.匹莫林镁:对大鼠电惊厥休克后记忆的增强作用
Life Sci. 1966 Aug;5(16):1495-8. doi: 10.1016/0024-3205(66)90224-4.

引用本文的文献

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Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline.
Br J Clin Pharmacol. 1980 Nov;10(5):465-72. doi: 10.1111/j.1365-2125.1980.tb01790.x.
2
Effects of methylphenidate (Ritalin) on selective attention in hyperactive children.哌甲酯(利他林)对多动症儿童选择性注意力的影响。
J Abnorm Child Psychol. 1979 Dec;7(4):471-81. doi: 10.1007/BF00917617.
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PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.
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