蚊子生长和衰老过程中的烟酰胺腺嘌呤二核苷酸磷酸酶
Nicotinamide-adenine dinucleotide phosphate enzymes in the mosquito during growth and aging.
作者信息
Lang C A, Stephan J K
出版信息
Biochem J. 1967 Jan;102(1):331-7. doi: 10.1042/bj1020331.
Abstract
- Optimum conditions were established for determining the activities of the NADP(+)-linked enzymes, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase, in mosquito tissues. 2. The activity of each dehydrogenase was determined in samples of mosquitoes of different ages throughout the life-span. The specific-activity curves attained maximal values in the pupal or early adult period. From these maxima an 81% decrease in glucose 6-phosphate-dehydrogenase and 67% decrease in 6-phosphogluconate-dehydrogenase activities occurred after the tenth day of adult life; a 77% decrease in isocitrate-dehydrogenase activity occurred before the fifth day. 3. The activity differences were found in different body regions as well as in whole organisms. 4. Starvation of the larva or adult did not result in decreases in enzyme activity. 5. These findings support the hypothesis that the activities of enzymes that form NADPH are related to the biosynthetic activity, for the enzyme activities increased during the period of cellular growth and decreased during the aging period.
摘要
- 确定了在蚊虫组织中测定与NADP(+)相关的酶（葡萄糖6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶和异柠檬酸脱氢酶）活性的最佳条件。2. 在整个生命周期内，测定了不同年龄蚊虫样本中每种脱氢酶的活性。每种脱氢酶的比活性曲线在蛹期或成虫早期达到最大值。从这些最大值来看，成虫期第10天后，葡萄糖6-磷酸脱氢酶活性下降81%，6-磷酸葡萄糖酸脱氢酶活性下降67%；异柠檬酸脱氢酶活性在第5天前下降77%。3. 在不同身体部位以及整个生物体中都发现了活性差异。4. 幼虫或成虫饥饿并未导致酶活性下降。5. 这些发现支持了这样的假说，即形成NADPH的酶的活性与生物合成活性相关，因为酶活性在细胞生长期间增加，而在衰老期间下降。
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1
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2
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J Biol Chem. 1951 Mar;189(1):123-36.
3
Enzyme patterns in rat liver and Morris hepatoma 5123 during metabolic transitions.大鼠肝脏和莫里斯肝癌5123在代谢转变过程中的酶模式。
Cold Spring Harb Symp Quant Biol. 1961;26:355-62. doi: 10.1101/sqb.1961.026.01.043.
4
PROTEIN AND NUCLEIC ACID CHANGES DURING GROWTH AND AGING IN THE MOSQUITO.蚊子生长和衰老过程中的蛋白质与核酸变化
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Adv Enzyme Regul. 1963;1:121-36. doi: 10.1016/0065-2571(63)90013-x.
6
Changes in patterns of enzymes of carbohydrate metabolism in the developing rat liver.发育中大鼠肝脏碳水化合物代谢酶模式的变化
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