Stanfield B B, Caviness V S, Cowan W M
J Comp Neurol. 1979 Jun 1;185(3):461-83. doi: 10.1002/cne.901850304.
The organization of certain of the major afferents to the hippocampus and dentate gyrus has been studied in normal and reeler mutant mice using the autoradiographic and the anterograde degeneration methods. The distribution of the hippocampal and dentate afferents which arise in the medial and lateral parts of the entorhinal cortex and the hippocampus of both sides, has been found to be generally similar to that previously described in the rat, but there are a few minor differences that are discussed in the text. Despite the marked ectopia of many of the neurons in the hippocampal formation in the reeler mouse, the principal afferents to the hippocampus and the dentate gyrus maintain many of the features seen in normal mice. In particular, they maintain a normal radial sequence and a characteristic laminated and complementary arrangement. However, there are a number of significant differences in their distribution; for example, in the reeler mouse, the entorhinal afferents occupy the entire radial extent of the stratum moleculare of the dentate gyrus, whereas in normal mice they are restricted to the outer four-fifths of this layer. Furthermore, in the mutant the commissural and associational afferents to the dentate gyrus do not occupy the inner one-fifth of the molecular layer (as they do in normal animals) but rather are spread throughout the zone containing granule cells, which includes both the poorly-defined stratum granulosum and most of the hilar region of the dentate gyrus. Some of the developmental and functional implications of these and other abnormalities in the organization of the afferents to the hippocampus and dentate gyrus are discussed.
运用放射自显影法和顺行性变性法，对正常小鼠和reeler突变小鼠中某些传入海马体和齿状回的主要神经纤维的组织情况进行了研究。已发现，起源于内嗅皮质内侧和外侧部分以及双侧海马体的海马体和齿状回传入纤维的分布，总体上与先前在大鼠中描述的情况相似，但文中讨论了一些细微差异。尽管reeler小鼠海马结构中的许多神经元存在明显的异位，但传入海马体和齿状回的主要神经纤维仍保留了正常小鼠中所见的许多特征。特别是，它们保持了正常的放射状排列顺序以及特征性的分层和互补排列。然而，它们的分布存在一些显著差异；例如，在reeler小鼠中，内嗅传入纤维占据齿状回分子层的整个放射状范围，而在正常小鼠中，它们仅限于该层的外五分之四。此外，在突变体中，传入齿状回的连合纤维和联合纤维并不占据分子层的内五分之一（正常动物中是这样），而是散布在包含颗粒细胞的区域，该区域包括定义不清的颗粒层和齿状回的大部分门区。文中还讨论了这些以及海马体和齿状回传入纤维组织中其他异常情况的一些发育和功能意义。
