Olitzki A L, Olitzki Z, Davis C L
Appl Microbiol. 1968 Mar;16(3):500-5. doi: 10.1128/am.16.3.500-505.1968.
Of six antibiotics investigated, streptovaricin C had the most marked chemotherapeutic effect on Mycobacterium kansasii infections in mice. By the intraperitoneal route this antibiotic caused elimination of the pathogens from all organs. Kanamycin eliminated the pathogens from the lungs of all animals and from the spleens and livers of most of them. Bluensomycin also removed the pathogens from the lungs of all animals, and spectinomycin and lincomycin, from the lungs of the majority of the animals. The three latter antibiotics lowered the bacterial counts in liver and spleen. Streptovaricin C also decreased the bacterial counts in brain, spleen, and liver of mice inoculated intracerebrally with M. kansasii. In one experiment it completely eliminated this pathogen from the spleen and almost completely from the liver. The effect of streptovaricin C on the cerebral infection was more marked than that of streptovaricin complex. Respiratory and cerebral infections of mice with M. avium, serotypes I and II, were limited by streptovaricin C, and marked decreases of the bacterial counts in brain, lungs, spleen, and liver were observed.
在所研究的六种抗生素中，链黑菌素C对小鼠堪萨斯分枝杆菌感染具有最显著的化疗效果。通过腹腔注射途径，这种抗生素可使所有器官中的病原体被清除。卡那霉素可使所有动物肺部以及大多数动物脾脏和肝脏中的病原体被清除。蓝霉素也能清除所有动物肺部的病原体，壮观霉素和林可霉素则可清除大多数动物肺部的病原体。后三种抗生素可降低肝脏和脾脏中的细菌数量。链黑菌素C还可降低经脑内接种堪萨斯分枝杆菌的小鼠脑、脾和肝脏中的细菌数量。在一项实验中，它完全清除了脾脏中的这种病原体，几乎完全清除了肝脏中的病原体。链黑菌素C对脑部感染的效果比对链黑菌素复合物的效果更显著。链黑菌素C可限制I型和II型血清型鸟分枝杆菌对小鼠的呼吸道和脑部感染，并观察到脑、肺、脾和肝脏中的细菌数量显著减少。
