Olitzki A L, Godinger D, Israeli M, Honigman A
Appl Microbiol. 1967 Sep;15(5):994-1001. doi: 10.1128/am.15.5.994-1001.1967.
Examination of the bactericidal and bacteriostatic effects of nine antibiotics on atypical mycobacteria revealed that streptovaricin complex and streptovaricin C exerted bactericidal effects on several strains in concentrations lower than 1.0 mug/ml. An exposure to the drug for 48 hr at 37 C was necessary to effect a complete inactivation of more than 99.9% of the exposed microorganisms. The appearance of strepto-varicin-resistant mutants was observed. However, these mutants were unstable, and reversion to streptovaricin susceptibility occurred. Celesticetin salicylate, added in a concentration of 100.0 mug/ml to the medium of Olitzki and Gershon inoculated with Mycobacterium leprae, effected a complete change of the uniformly stained mycobacteria to bipolarity, which indicates the devitalization of this microorganism.
对九种抗生素对非典型分枝杆菌的杀菌和抑菌作用进行检测发现，链黑菌素复合物和链黑菌素C对几种菌株在浓度低于1.0微克/毫升时具有杀菌作用。在37℃下将药物暴露48小时对于使超过99.9%的暴露微生物完全失活是必要的。观察到了对链黑菌素耐药的突变体。然而，这些突变体不稳定，会恢复对链黑菌素的敏感性。将浓度为100.0微克/毫升的水杨酸天青菌素添加到接种了麻风分枝杆菌的奥利茨基和格申培养基中，使均匀染色的分枝杆菌完全变为双极性，这表明该微生物已失去活力。
