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Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.

作者信息

Gigon P L, Gram T E, Gillette J R

出版信息

Biochem Biophys Res Commun. 1968 May 23;31(4):558-62. doi: 10.1016/0006-291x(68)90514-7.

DOI:10.1016/0006-291x(68)90514-7
PMID:4385338
Abstract
摘要

相似文献

1
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Biochem Biophys Res Commun. 1968 May 23;31(4):558-62. doi: 10.1016/0006-291x(68)90514-7.
2
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Mol Pharmacol. 1969 Mar;5(2):109-22.
3
Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.关于各种物质对细胞色素P - 450吸收光谱的影响与小鼠肝微粒体对硝基苯甲酸还原作用之间关系的研究。
Mol Pharmacol. 1969 Mar;5(2):123-30.
4
Spectral studies of drug interaction with hepatic microsomal cytochrome.药物与肝微粒体细胞色素相互作用的光谱研究
Mol Pharmacol. 1967 Mar;3(2):113-23.
5
Metabolism of drugs in old rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of old rats.
Jpn J Pharmacol. 1968 Dec;18(4):381-8. doi: 10.1254/jjp.18.381.
6
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.3-氨基三唑给药对大鼠肝脏微粒体药物代谢酶系统活性的影响。
Jpn J Pharmacol. 1967 Mar;17(1):56-63. doi: 10.1254/jjp.17.56.
7
An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate.一种关于肝微粒体药物代谢与还原型烟酰胺腺嘌呤二核苷酸磷酸氧化之间化学计量关系的方法测量。
Mol Pharmacol. 1972 Mar;8(2):189-96.
8
Species differences in the effect of morphine administration or adrenalectomy on the substrate interactions with cytochrome P-450 and drug oxidations by liver microsomes.
Biochem Pharmacol. 1971 Jun;20(6):1093-9. doi: 10.1016/0006-2952(71)90338-8.
9
Effects of morphine treatment and starvation on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes.
Jpn J Pharmacol. 1970 Jun;20(2):194-209. doi: 10.1254/jjp.20.194.
10
Effect of thyroid hormone on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes.甲状腺激素对肝脏微粒体氧化药物过程中底物与P - 450相互作用的影响。
J Biochem. 1970 Nov;68(5):613-23. doi: 10.1093/oxfordjournals.jbchem.a129395.

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Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.已上市药物可抑制细胞色素P450 27A1，这是乳腺癌辅助治疗的一个潜在新靶点。
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Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.药物刺激细胞色素 P450 46A1 和小鼠大脑胆固醇周转。
J Biol Chem. 2014 Feb 7;289(6):3529-38. doi: 10.1074/jbc.M113.532846. Epub 2013 Dec 18.
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Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
氰基和氟代药物比卡鲁胺与细胞色素 P45046A1 的结合：异常特征和光谱响应。
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Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.治疗药物对纯化重组 CYP11A1 活性的抑制和刺激作用。
Mol Cell Endocrinol. 2013 May 22;371(1-2):100-6. doi: 10.1016/j.mce.2012.10.013. Epub 2012 Oct 23.
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The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction.细胞色素 P450 代谢 II 型结合化合物的动力学机制：支持直接还原的证据。
Arch Biochem Biophys. 2011 Jul;511(1-2):69-79. doi: 10.1016/j.abb.2011.04.008. Epub 2011 Apr 21.
6
The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells.肝细胞粗面内质网和滑面内质网中混合功能氧化酶各组分的分布。
Biochem J. 1968 Dec;110(3):407-12. doi: 10.1042/bj1100407.
7
Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats.雄性大鼠出生后发育和成熟过程中肝脏微粒体苯胺羟化酶和乙基吗啡脱甲基酶某些动力学特性的变化。
Biochem J. 1969 Jul;113(4):681-5. doi: 10.1042/bj1130681.
8
Spin-state changes in cytochrome P-450cam on binding of specific substrates.细胞色素P-450cam与特定底物结合时的自旋态变化。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1157-63. doi: 10.1073/pnas.66.4.1157.
9
Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro.脱辅基细胞色素P-450：体外利用血红素重建功能性细胞色素
Proc Natl Acad Sci U S A. 1975 Jan;72(1):400-4. doi: 10.1073/pnas.72.1.400.
10
Growth hormone and drug metabolism. Acute effects on microsomal mixed-function oxidase activities in rat liver.生长激素与药物代谢。对大鼠肝脏微粒体混合功能氧化酶活性的急性影响。
Biochem J. 1976 Feb 15;154(2):433-8. doi: 10.1042/bj1540433.