影响胎鼠肝脏中酪氨酸转氨酶过早诱导的因素。
Factors affecting the premature induction of tyrosine aminotransferase in foetal rat liver.
作者信息
Holt P G, Oliver I T
出版信息
Biochem J. 1968 Jun;108(2):333-8. doi: 10.1042/bj1080333.
Abstract
- Premature delivery of foetal rats by uterine section results in the rapid appearance of tyrosine aminotransferase activity in foetal liver, after an initial lag period of 3-6hr. 2. The premature induction of activity is completely repressible by actinomycin D given soon after delivery and partially repressible by puromycin and amino acid analogues. 3. Glucagon injections into foetal rats in utero lead to production of tyrosine aminotransferase in the foetal liver, but adrenalin and nor-adrenalin are without effect. 4. Injections of glucose, galactose, fructose and mannose into prematurely delivered rats repress the development of tyrosine aminotransferase activity about 50% when they are given 2hr. after delivery, but glucose has no significant effect when injected at delivery. 5. The results are discussed in relation to current hypotheses on the role of hormones in enzyme induction in foetal development.
摘要
- 通过子宫切开术使胎鼠早产，在最初3 - 6小时的延迟期后，胎鼠肝脏中酪氨酸转氨酶活性迅速出现。2. 分娩后不久给予放线菌素D可完全抑制活性的过早诱导，嘌呤霉素和氨基酸类似物可部分抑制。3. 对子宫内的胎鼠注射胰高血糖素可导致胎鼠肝脏产生酪氨酸转氨酶，但肾上腺素和去甲肾上腺素无此作用。4. 对早产大鼠在分娩后2小时注射葡萄糖、半乳糖、果糖和甘露糖，可使酪氨酸转氨酶活性的发育受到约50%的抑制，但在分娩时注射葡萄糖则无显著影响。5. 根据目前关于激素在胎儿发育中酶诱导作用的假说对结果进行了讨论。
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1
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2
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3
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Biochim Biophys Acta. 1964 Jun 22;87:212-8.
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