抗胰岛素药物在子宫内诱导酪氨酸转氨酶生成。
Induction of tyrosine aminotransferase in utero by anti-insulin agents.
作者信息
Cake M H
出版信息
Biochem J. 1986 Sep 15;238(3):927-9. doi: 10.1042/bj2380927.
Abstract
The hepatic enzyme tyrosine aminotransferase, normally expressed in very low amounts until shortly after birth, is prematurely induced in foetal rats made diabetic by the administration of streptozotocin in utero. Similarly, the enzyme is precociously induced in foetuses if the circulating insulin concentration is artificially decreased by the administration of anti-insulin serum. These observations support the proposal that the natural decrease in plasma insulin, known to occur at birth, is a major contributor to the postnatal induction of tyrosine aminotransferase.
摘要
肝酶酪氨酸转氨酶在出生前不久通常以极低的量表达，而在子宫内注射链脲佐菌素致糖尿病的胎鼠中会过早诱导其表达。同样，如果通过注射抗胰岛素血清人为降低循环胰岛素浓度，该酶也会在胎儿中过早诱导表达。这些观察结果支持了这样一种观点，即已知在出生时发生的血浆胰岛素自然下降是酪氨酸转氨酶出生后诱导的主要因素。
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