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来自蟾鱼胰岛组织的胰岛素分泌受吡啶核苷酸刺激。

Insulin secretion from toadfish islet tissue stimulated by pyridine nucleotides.

作者信息

Watkins D, Cooperstein S J, Dixit P K, Lazarow A

出版信息

Science. 1968 Oct 11;162(3850):283-4. doi: 10.1126/science.162.3850.283.

DOI:10.1126/science.162.3850.283
PMID:4386347
Abstract

The addition of glucose stimulated release of insulin from the isolated islet tissue of the toadfish incubated in vitro. Reduced nicotinamide-adenine dinucleotide also stimulated insulin release, whereas the oxidized form had no effect. Both oxidized and reduced nicotinamide-adenine dinucleatide phosphate stimulated insulin release, but the reduced form was significantly more effective.

摘要

添加葡萄糖可刺激在体外培养的蟾鱼分离胰岛组织释放胰岛素。还原型烟酰胺腺嘌呤二核苷酸也可刺激胰岛素释放，而氧化型则无此作用。氧化型和还原型烟酰胺腺嘌呤二核苷酸磷酸均能刺激胰岛素释放，但还原型的效果显著更强。

相似文献

1
Insulin secretion from toadfish islet tissue stimulated by pyridine nucleotides.来自蟾鱼胰岛组织的胰岛素分泌受吡啶核苷酸刺激。
Science. 1968 Oct 11;162(3850):283-4. doi: 10.1126/science.162.3850.283.
2
Stimulation of insulin secretion by pyridine nucleotides.吡啶核苷酸对胰岛素分泌的刺激作用。
Endocrinology. 1971 Jun;88(6):1380-4. doi: 10.1210/endo-88-6-1380.
3
Pyridine nucleotide stimulation of insulin release from isolated toadfish insulin secretion granules.吡啶核苷酸对从分离的蟾鱼胰岛素分泌颗粒释放胰岛素的刺激作用。
Endocrinology. 1972 Jan;90(1):272-6. doi: 10.1210/endo-90-1-272.
4
Uptake of NADPH by islet secretion granule membranes.胰岛分泌颗粒膜对还原型辅酶Ⅱ的摄取。
Endocrinology. 1977 May;100(5):1461-7. doi: 10.1210/endo-100-5-1461.
5
The role of the pentose phosphate shunt in glucose induced insulin release: in vitro studies with 6-aminonicotinamide, methylene blue, NAD + , NADH, NADP + , NADPH and nicotinamide on isolated pancreatic rat islets.磷酸戊糖途径在葡萄糖诱导的胰岛素释放中的作用：用6-氨基烟酰胺、亚甲蓝、NAD⁺、NADH、NADP⁺、NADPH和烟酰胺对离体大鼠胰岛进行的体外研究。
Biochim Biophys Acta. 1973 Feb 28;297(2):352-67. doi: 10.1016/0304-4165(73)90083-4.
6
Effect of Methylene Blue on pyridine nucleotides and insulin secretion of rat pancreatic islets.亚甲蓝对大鼠胰岛吡啶核苷酸及胰岛素分泌的影响。
Diabetologia. 1979 Jul;17(1):41-4. doi: 10.1007/BF01222976.
7
Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin.外源性胰岛素抑制胰岛素释放过程中胰岛中的吡啶核苷酸
Endocrinology. 1976 Dec;99(6):1469-76. doi: 10.1210/endo-99-6-1469.
8
The role of old age in the effects of glucose on insulin secretion, pentosephosphate shunt activity, pyridine nucleotides and glutathione of rat pancreatic islets.衰老在葡萄糖对大鼠胰岛胰岛素分泌、磷酸戊糖途径活性、吡啶核苷酸和谷胱甘肽影响中的作用。
Life Sci. 1984 Jan 16;34(3):247-57. doi: 10.1016/0024-3205(84)90596-4.
9
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.葡萄糖诱导的胰岛素释放的刺激-分泌偶联。外源性丙酮酸对胰岛功能的影响。
Biochem J. 1978 Oct 15;176(1):217-32. doi: 10.1042/bj1760217.
10
Pentose phosphate shunt, pyridine nucleotides, glutathione, and insulin secretion of fetal islets.磷酸戊糖途径、吡啶核苷酸、谷胱甘肽与胎儿胰岛的胰岛素分泌
Am J Physiol. 1983 Apr;244(4):E354-60. doi: 10.1152/ajpendo.1983.244.4.E354.

引用本文的文献

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Acta Diabetol Lat. 1982 Jan-Mar;19(1):37-47. doi: 10.1007/BF02581184.
2
Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog. Biochemical and ultrastructural studies.化学诱导（链脲佐菌素-四氧嘧啶）犬糖尿病。生化及超微结构研究。
Am J Pathol. 1980 Feb;98(2):295-310.
3
[Effects of the intravenous infusion of nicotinic acid on blood concentrations of substrates, metabolites and hormones in juvenile-onset diabetes].
[静脉输注烟酸对青少年发病型糖尿病患者体内底物、代谢产物及激素血浓度的影响]
Diabetologia. 1970 Dec;6(6):550-7. doi: 10.1007/BF00418220.
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Insulin biosynthesis in the bullhead, Ictalurus nebulosus, and the effect of temperature.鲶鱼（Ictalurus nebulosus）的胰岛素生物合成及其温度效应。
Biochem J. 1973 Jul;134(3):753-61. doi: 10.1042/bj1340753.
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Effect of pyridine nucleotide precursors on the permeability of toad bladder in the presence of vasopression, adenosine 3':5'-cyclic monophosphate, and theophylline.吡啶核苷酸前体在存在血管加压素、腺苷 3':5'-环磷酸和茶碱的情况下对蟾蜍膀胱通透性的影响。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1221-4. doi: 10.1073/pnas.67.3.1221.
6
[Influence of nicotinic acid on insulin release in vitro].[烟酸对体外胰岛素释放的影响]
Acta Diabetol Lat. 1972 Jan-Feb;9(1):87-96. doi: 10.1007/BF01564541.
7
Islet-cell metabolism during insulin release. Effects of glucose, citrate, octanoate, tolbutamide, glucagon and theophylline.胰岛素释放过程中的胰岛细胞代谢。葡萄糖、柠檬酸盐、辛酸、甲苯磺丁脲、胰高血糖素和茶碱的作用。
Biochem J. 1969 Nov;115(2):257-62. doi: 10.1042/bj1150257.
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9
Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.超氧化物歧化酶、过氧化氢酶和羟自由基清除剂可在体外保护胰岛细胞免受四氧嘧啶的毒性作用。
Biochem J. 1979 Jul 15;182(1):17-25. doi: 10.1042/bj1820017.
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The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.葡萄糖诱导的胰岛素释放的刺激-分泌偶联。NH4+对大鼠胰岛的代谢和功能影响。
J Clin Invest. 1978 Oct;62(4):868-78. doi: 10.1172/JCI109199.