Gustafsson J
J Lipid Res. 1979 Feb;20(2):265-70.
The metabolism of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid was studied in the bile fistula rats and in preparations from rat liver homogenates. In the bile fistula rats, the main products were chenodeoxycholic acid, alpha-muricholic acid, and beta-muricholic acid. Only small amounts of cholic acid were formed. Incubations of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid with microsomes and NADPH yielded as the main product 3 alpha, 6 beta, 7 alpha-trihydroxy-5 beta-cholestanoic acid. The formation of small amounts of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid was shown. The major product in incubations of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid with microsomes and the 100,000 g supernatant fluid fortified with ATP was identified as 3 alpha, 7 alpha, 24 xi-trihydroxy-5 beta-cholestanoic acid. This compound was converted into chenodeoxycholic acid and its metabolites in the bile fistula rat.
在胆瘘大鼠及大鼠肝脏匀浆制备物中研究了3α,7α-二羟基-5β-胆甾烷酸的代谢。在胆瘘大鼠中，主要产物为鹅去氧胆酸、α-鼠胆酸和β-鼠胆酸。仅形成少量胆酸。3α,7α-二羟基-5β-胆甾烷酸与微粒体及NADPH温育，产生的主要产物为3α,6β,7α-三羟基-5β-胆甾烷酸。已表明形成少量3α,7α,12α-三羟基-5β-胆甾烷酸。3α,7α-二羟基-5β-胆甾烷酸与微粒体及用ATP强化的100,000g上清液温育时的主要产物被鉴定为3α,7α,24ξ-三羟基-5β-胆甾烷酸。该化合物在胆瘘大鼠中转化为鹅去氧胆酸及其代谢产物。
