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1
The catabolism of cholesterol in vitro. Formation of 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoic acid from cholesterol by rat liver.胆固醇在体外的分解代谢。大鼠肝脏将胆固醇转化为3-α,7-α,12-α-三羟基-5-β-胆甾烷酸。
Biochem J. 1969 Aug;114(1):1-3. doi: 10.1042/bj1140001.
2
Biosynthesis of cholic acid in rat liver. 24-Hydroxylation of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestanoic acid.大鼠肝脏中胆酸的生物合成。3α,7α,12α-三羟基-5β-胆甾烷酸的24-羟基化作用。
J Biol Chem. 1975 Oct 25;250(20):8243-7.
3
Effect of the side-chain structure on the specificity of beta-oxidation in bile acid biosynthesis in rat liver homogenates.侧链结构对大鼠肝脏匀浆中胆汁酸生物合成中β-氧化特异性的影响。
J Lipid Res. 1997 Dec;38(12):2589-602.
4
Synthesis of coenzyme A esters of 3alpha,7alpha,12alpha-trihydroxy- and 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oic acids for the study of beta-oxidation in bile acid biosynthesis.合成3α,7α,12α-三羟基-和3α,7α-二羟基-24-氧代-5β-胆甾烷-26-酸的辅酶A酯用于胆汁酸生物合成中β-氧化的研究。
Steroids. 2001 Jun;66(6):499-504. doi: 10.1016/s0039-128x(00)00209-9.
5
Structural and biosynthetic studies of a principal bile alcohol, 27-nor-5beta-cholestane-3alpha,7alpha,12alpha,24,25-pentol, in human urine.人尿中主要胆汁醇27-降-5β-胆甾烷-3α,7α,12α,24,25-戊醇的结构与生物合成研究
J Lipid Res. 2000 Oct;41(10):1562-7.
6
Formation of bile acids in man: conversion of cholesterol into 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol in liver homogenates.人体内胆汁酸的形成：肝脏匀浆中胆固醇向5-β-胆甾烷-3-α,7-α,12-α-三醇的转化
J Clin Invest. 1968 Jul;47(7):1573-82. doi: 10.1172/JCI105849.
7
Metabolism of bile alcohols in the perfused rabbit liver.灌注兔肝脏中胆汁醇的代谢
J Biol Chem. 1976 May 10;251(9):2709-15.
8
Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid.培养的人肝细胞中的胆汁酸合成：对胆酸替代生物合成途径的支持。
Hepatology. 2000 Jun;31(6):1305-12. doi: 10.1053/jhep.2000.7877.
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Two Major Bile Acids in the Hornbills, (24R,25S)-3α,7α,24-Trihydroxy-5β-cholestan-27-oyl Taurine and Its 12α-Hydroxy Derivative.犀鸟体内的两种主要胆汁酸，(24R,25S)-3α,7α,24-三羟基-5β-胆甾烷-27-酰牛磺酸及其12α-羟基衍生物。
Lipids. 2016 Jun;51(6):757-68. doi: 10.1007/s11745-016-4150-0. Epub 2016 Apr 23.
10
Analyses of bile from gallbladders of Arius platystomus, Arius tenuispinis, Pomadasys commersonni and Kishinoella tonggol.对宽口海鲶、细棘海鲶、康氏鲾和长吻基齿鲨胆囊胆汁的分析。
Pak J Pharm Sci. 2015 Jul;28(4):1253-8.

引用本文的文献

1
Effect of the exotoxin of Bacillus thuringiensis on normal and ecdysone-stimulated ribonucleic acid polymerase activity in intact nuclei from the fat-body of Sarcophaga bullata larvae.苏云金芽孢杆菌外毒素对麻蝇幼虫脂肪体完整细胞核中正常及蜕皮激素刺激的核糖核酸聚合酶活性的影响。
Biochem J. 1973 Sep;136(1):1-7. doi: 10.1042/bj1360001.
2
Differential inhibition of mammalian ribonucleic acid polymerases by an exotoxin from Bacillus thuringiensis. The direct observation of nucleoplasmic ribonucleic acid polymerase activity in intact nuclei.苏云金芽孢杆菌产生的一种外毒素对哺乳动物核糖核酸聚合酶的差异性抑制作用。完整细胞核中核质核糖核酸聚合酶活性的直接观察。
Biochem J. 1972 May;127(4):619-34. doi: 10.1042/bj1270619.

本文引用的文献

1
CONVERSION OF CHOLESTEROL TO TRIHYDROXYCOPROSTANIC ACID AND CHOLIC ACID IN MAN.人体内胆固醇向三羟基粪甾烷酸和胆酸的转化
J Clin Invest. 1964 Jul;43(7):1443-8. doi: 10.1172/JCI105020.
2
THE IN VITRO CATABOLISM OF CHOLESTEROL: FORMATION OF 3-ALPHA,7-ALPHA,12-ALPHA-TRIHYDROXYCOPROSTANE FROM CHOLESTEROL IN RAT LIVER.胆固醇的体外代谢：大鼠肝脏中胆固醇生成3-α,7-α,12-α-三羟基粪甾烷
Biochemistry. 1963 May-Jun;2:577-9. doi: 10.1021/bi00903a033.
3
Crystallization of trihydroxycoprostani acid from human bile.三羟基前列腺烷酸在人胆汁中的结晶
J Biol Chem. 1963 Feb;238:855-6.
4
Mechanism of formation of bile acids from cholesterol: oxidation of 5bita-choles-tane-3alpha,7alpha,12alpha-triol and formation of propionic acid from the side chain by rat liver mitochondria.胆固醇生成胆汁酸的机制：大鼠肝脏线粒体对5β-胆甾烷-3α,7α,12α-三醇的氧化作用以及侧链生成丙酸的过程。
J Biol Chem. 1962 Feb;237:338-44.
5
Formation of trihydroxycoprostanic acid from cholesterol in man.人体内胆固醇形成三羟基粪甾烷酸的过程。
Biochim Biophys Acta. 1962 Jun 4;59:735-6. doi: 10.1016/0006-3002(62)90663-7.
6
Partial synthesis of the two 3alpha:7alpha:12alpha-trihydroxycoprostanic acids and of similar bile acids with extended chains.两种3α:7α:12α-三羟基粪甾烷酸以及具有延长链的类似胆汁酸的部分合成。
Biochem J. 1956 Dec;64(4):593-9. doi: 10.1042/bj0640593a.
7
The incorporation of the carboxyl carbon from acetate into cholesterol by rat liver homogenates.大鼠肝脏匀浆将乙酸盐中的羧基碳掺入胆固醇的过程。
J Biol Chem. 1954 Jan;206(1):471-81.
8
Comparative studies of bile salts. VI. Partial synthesis of coprostanic acid, a stem acid of primitive bile salts.胆汁盐的比较研究。VI. 原胆烷酸（一种原始胆汁盐的母体酸）的部分合成。
Biochem J. 1952 Dec;52(4):588-90. doi: 10.1042/bj0520588.
9
Comparative studies of bile salts. V. Bile salts of Crocodylidae.胆汁盐的比较研究。V. 鳄科动物的胆汁盐。
Biochem J. 1952 Dec;52(4):583-7. doi: 10.1042/bj0520583.
10
The in vitro catabolism of cholesterol. Formation of cholic acid from cholesterol in rat liver.胆固醇的体外分解代谢。大鼠肝脏中胆固醇转化为胆酸。
Biochemistry. 1966 Oct;5(10):3194-8. doi: 10.1021/bi00874a018.

胆固醇在体外的分解代谢。大鼠肝脏将胆固醇转化为3-α,7-α,12-α-三羟基-5-β-胆甾烷酸。

The catabolism of cholesterol in vitro. Formation of 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoic acid from cholesterol by rat liver.

作者信息

Mendelsohn D, Mendelsohn L

出版信息

Biochem J. 1969 Aug;114(1):1-3. doi: 10.1042/bj1140001.

DOI:10.1042/bj1140001
PMID:5810058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184787/
Abstract
  1. Both 25-d- and 25-l-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid were isolated from the gall-bladder bile of Crocodylus niloticus. 2. The catabolism of cholesterol to 25-d- and 25-l-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid respectively was studied by using a rat liver preparation in vitro. The results show that rat liver can metabolize cholesterol to both forms of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. However, a preference was noted for the formation from [4-(14)C]cholesterol of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (25-d), which was isolated from the incubations with a specific radioactivity about four times that of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (25-l). 3. The results indicate that 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid is a normal intermediate in the biosynthesis of bile acids from cholesterol in the rat.
摘要
  1. 从尼罗鳄的胆囊胆汁中分离出了25-d-和25-l-3α,7α,12α-三羟基-5β-胆甾烷酸。2. 通过使用大鼠肝脏体外制剂，研究了胆固醇分别代谢为25-d-和25-l-3α,7α,12α-三羟基-5β-胆甾烷酸的过程。结果表明，大鼠肝脏能够将胆固醇代谢为两种形式的3α,7α,12α-三羟基-5β-胆甾烷酸。然而，发现从[4-(14)C]胆固醇形成3α,7α,12α-三羟基-5β-胆甾烷酸（25-d）具有偏好性，从孵育物中分离出的该物质的比放射性约为3α,7α,12α-三羟基-5β-胆甾烷酸（25-l）的四倍。3. 结果表明在大鼠体内，3α,7α,12α-三羟基-5β-胆甾烷酸是胆固醇生物合成胆汁酸过程中的正常中间体。