胆固醇在体外的分解代谢。大鼠肝脏将胆固醇转化为3-α,7-α,12-α-三羟基-5-β-胆甾烷酸。
The catabolism of cholesterol in vitro. Formation of 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoic acid from cholesterol by rat liver.
作者信息
Mendelsohn D, Mendelsohn L
出版信息
Biochem J. 1969 Aug;114(1):1-3. doi: 10.1042/bj1140001.
Abstract
- Both 25-d- and 25-l-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid were isolated from the gall-bladder bile of Crocodylus niloticus. 2. The catabolism of cholesterol to 25-d- and 25-l-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid respectively was studied by using a rat liver preparation in vitro. The results show that rat liver can metabolize cholesterol to both forms of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. However, a preference was noted for the formation from [4-(14)C]cholesterol of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (25-d), which was isolated from the incubations with a specific radioactivity about four times that of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (25-l). 3. The results indicate that 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid is a normal intermediate in the biosynthesis of bile acids from cholesterol in the rat.
摘要
- 从尼罗鳄的胆囊胆汁中分离出了25-d-和25-l-3α,7α,12α-三羟基-5β-胆甾烷酸。2. 通过使用大鼠肝脏体外制剂，研究了胆固醇分别代谢为25-d-和25-l-3α,7α,12α-三羟基-5β-胆甾烷酸的过程。结果表明，大鼠肝脏能够将胆固醇代谢为两种形式的3α,7α,12α-三羟基-5β-胆甾烷酸。然而，发现从[4-(14)C]胆固醇形成3α,7α,12α-三羟基-5β-胆甾烷酸（25-d）具有偏好性，从孵育物中分离出的该物质的比放射性约为3α,7α,12α-三羟基-5β-胆甾烷酸（25-l）的四倍。3. 结果表明在大鼠体内，3α,7α,12α-三羟基-5β-胆甾烷酸是胆固醇生物合成胆汁酸过程中的正常中间体。
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