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肺炎球菌多糖抗体：结合与电泳异质性之间的关系

Antibodies to pneumococcal polysaccharides: relation between binding and electrophoretic heterogeneity.

作者信息

Pincus J H, Haber E, Katz M, Pappenheimer A M

出版信息

Science. 1968 Nov 8;162(3854):667-8. doi: 10.1126/science.162.3854.667.

DOI:10.1126/science.162.3854.667
PMID:4386872
Abstract

Antibodies to type III and type VIII pneumococcal polysaccharides were examined with respect to ligand binding and electrophoretic heterogeneity. Both antibodies showed apparent binding homogeneity, although multiple light chain and heavy chain electrophoretic species were demonstrated.

摘要

对III型和VIII型肺炎球菌多糖抗体进行了配体结合和电泳异质性方面的检测。尽管证实存在多种轻链和重链电泳类型，但两种抗体均表现出明显的结合均一性。

相似文献

1
Antibodies to pneumococcal polysaccharides: relation between binding and electrophoretic heterogeneity.肺炎球菌多糖抗体：结合与电泳异质性之间的关系
Science. 1968 Nov 8;162(3854):667-8. doi: 10.1126/science.162.3854.667.
2
Antibodies to type III and type VIII pneumococcal polysaccharides: evidence for restricted structural heterogeneity in hyperimmunized rabbits.抗III型和VIII型肺炎球菌多糖抗体：高免疫兔中结构异质性受限的证据。
J Immunol. 1970 May;104(5):1143-8.
3
Persistence and characterization of idiotypes in pedigreed rabbits producing antibodies of restricted heterogeneity to pneumococcal polysaccharides.对肺炎球菌多糖产生具有有限异质性抗体的纯种兔中独特型的持久性及特性研究
J Immunol. 1972 May;108(5):1278-87.
4
Antibodies of restricted heterogeneity for structural study.用于结构研究的具有受限异质性的抗体。
Fed Proc. 1970 Jan-Feb;29(1):66-71.
5
Quantitative studies of the specificity of anti-pneumococcal polysaccharide antibodies, types 3 and 8. V. Cross-reacting antibodies in rabbit antisera.抗3型和8型肺炎球菌多糖抗体特异性的定量研究。V. 兔抗血清中的交叉反应抗体。
Immunochemistry. 1973 Apr;10(4):257-63. doi: 10.1016/0019-2791(73)90203-6.
6
Humoral and cellular responses of mice to a pneumococcal polysaccharide antigen. Circulating antibodies.小鼠对肺炎球菌多糖抗原的体液和细胞反应。循环抗体。
Aust J Exp Biol Med Sci. 1970 Apr;48(2):215-26. doi: 10.1038/icb.1970.21.
7
Isolation and characterization of structurally homogeneous antibodies from antipneumococcal sera.从抗肺炎球菌血清中分离和鉴定结构均一的抗体。
Proc Natl Acad Sci U S A. 1970 Jul;66(3):959-66. doi: 10.1073/pnas.66.3.959.
8
Properties of structurally restricted antibody to type VIII pneumococcal polysaccharide.针对 VIII 型肺炎球菌多糖的结构受限抗体的特性
J Immunol. 1970 May;104(5):1149-54.
9
Maturation of the immune response to type three pneumococcal polysaccharide.对3型肺炎球菌多糖免疫反应的成熟
Immunochemistry. 1972 Dec;9(12):1169-84. doi: 10.1016/0019-2791(72)90291-1.
10
Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.免疫麻痹研究。V. 分子量对3种肺炎球菌多糖的免疫原性、耐受性和抗体中和活性的影响
Immunology. 1971 Sep;21(3):535-46.

引用本文的文献

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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
J Exp Med. 1970 Aug 1;132(2):211-50. doi: 10.1084/jem.132.2.211.
2
Electrophoretically homogeneous anti-DNP antibodies with restricted isoelectric points elicited in mice by immunization with the antigen papain-S-DNPL.通过用抗原木瓜蛋白酶-S-DNPL免疫小鼠产生的具有受限等电点的电泳纯抗-DNP抗体。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):411-8. doi: 10.1073/pnas.66.2.411.
3
Degeneracy of the immune response to sheep red cells.
对绵羊红细胞免疫反应的简并性。
Immunology. 1972 Sep;23(3):321-34.
4
The anamnestic antibody response to type 3 specific pneumococcal polysaccharide.对3型特异性肺炎球菌多糖的回忆性抗体反应。
J Exp Med. 1969 Jul 1;130(1):77-89. doi: 10.1084/jem.130.1.77.