Karakawa W W, Kane J A, Austrian R
Infect Immun. 1973 Dec;8(6):969-76. doi: 10.1128/iai.8.6.969-976.1973.
A cell wall-associated polysaccharide has been isolated from a noncapsulated mutant, 89R50, of the alpha-hemolytic filamentous streptococcus of provisional capsular type 89. Chemical analysis of the polysaccharide indicates that it consists of galactosamine, glucosamine, glucose, and phosphorus. Immunological cross-reactivity was observed between the streptococcal cell wall antigen and antibody to the cell wall-like capsular polysaccharide of pneumococcus. This cross-reactivity appears attributable to similarities in the teichoic acid moieties rather than in the mucopeptide moieties of the two polymers. No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor. It is suggested that antibody to this cell wall polysaccharide might serve as a basis for grouping other filamentous strains of streptococci of diverse capsular types, the cell wall antigens of which show similar cross-reactivity with that of pneumococcus.
已从暂定荚膜89型的α溶血性丝状链球菌的无荚膜突变体89R50中分离出一种细胞壁相关多糖。对该多糖的化学分析表明，它由半乳糖胺、葡糖胺、葡萄糖和磷组成。在链球菌细胞壁抗原与针对肺炎球菌细胞壁样荚膜多糖的抗体之间观察到免疫交叉反应。这种交叉反应似乎归因于两种聚合物中磷壁酸部分的相似性，而非粘肽部分的相似性。在无荚膜链球菌89R50及其有荚膜的亲本菌株的细胞壁碳水化合物中未观察到化学或免疫差异。有人提出，针对这种细胞壁多糖的抗体可能作为对其他不同荚膜类型的丝状链球菌菌株进行分组的基础，这些菌株的细胞壁抗原与肺炎球菌的细胞壁抗原表现出相似的交叉反应。
