Wilson D W, Griffiths K, Kemp K W, Nix A B, Rowlands R J
J Endocrinol. 1979 Mar;80(3):365-72. doi: 10.1677/joe.0.0800365.
A cumulative sum technique has been specially designed to monitor the error between replicate determinations made on quality control plasma for consecutive batches of assays. This procedure has played a vital role in assessing assay performance. Special consideration has been given to small sample sizes (n = 2 or 3) which is generally the rule rather than the exception in many situations. This technique has been applied to numerous steroid radioimmunoassays and has ensured that both the mean value and the standard error of hormone levels of a quality control pool were under control. Data from routine assays of oestriol and testosterone in plasma from women are presented. Since this technique provides a sensitive measure of monitoring error, it assists the endocrinologist in elucidating statistical inferences which are a manifestation of assay performance.
一种累积求和技术经过专门设计，用于监测连续批次检测中对质量控制血浆进行重复测定之间的误差。该程序在评估检测性能方面发挥了至关重要的作用。对于小样本量（n = 2或3）给予了特别考虑，在许多情况下这通常是常态而非例外。该技术已应用于众多类固醇放射免疫分析，并确保了质量控制样本池激素水平的均值和标准误差均在可控范围内。文中给出了女性血浆中雌三醇和睾酮常规检测的数据。由于该技术提供了一种监测误差的灵敏方法，它有助于内分泌学家阐明作为检测性能表现的统计推断。
