Wenzel M, Hölscher B, Günther T, Merker H J
J Clin Chem Clin Biochem. 1979 Mar;17(3):123-8.
The tissue H2O of rabbit heart and rat liver was partially exchanged in situ with D2O. In rat liver, the loss of ATP, resulting from normothermic ischemia, was decreased after perfusion with D2O. The maximal protective effect was found when the proportion of D2O in the water of the liver tissue was 0.20. In both organs the protective effect of D2O could be correlated with a marked decrease in severe ischemic damage of cellular organelles, in particular mitochondria. D2O also increased the protective action of Mg-ions in the heart.
兔心脏和大鼠肝脏的组织水在原位与重水（D2O）进行了部分交换。在大鼠肝脏中，常温缺血导致的三磷酸腺苷（ATP）损失在用重水灌注后有所减少。当肝脏组织水中重水的比例为0.20时，发现其具有最大保护作用。在这两个器官中，重水的保护作用都与细胞器尤其是线粒体的严重缺血损伤显著减少相关。重水还增强了镁离子对心脏的保护作用。
