Fischer J H, Fuhs M, Miyata M, Wenzel M, Isselhard W
Chir Forum Exp Klin Forsch. 1980:129-33.
Rat livers were preserved by ischemic hypothermic storage in extra- or intracellular type solutions for 24 h. A substitution of 85% of the tissue water by deuterium oxide (D2O) resulted in increased glycolytic energy production, better maintenance of the energy potential of the cells but a higher AMP loss, and a reduction of edema formation. Preservation using "retrograde oxygen persufflation" (ROP) resulted in optimal maintenance of the metabolic state which could be further influenced positively by D2O in the total nucleotide content.
大鼠肝脏在细胞外或细胞内型溶液中通过缺血性低温保存24小时。用氧化氘（D2O）替代85%的组织水分可增加糖酵解能量产生，更好地维持细胞的能量电位，但AMP损失更高，并减少水肿形成。使用“逆行氧灌注”（ROP）保存可使代谢状态得到最佳维持，而D2O可进一步对总核苷酸含量产生积极影响。
