Kopp N, Denoroy L, Renaud B, Pujol J F, Tabib A, Tommasi M
J Neurol Sci. 1979 May;41(3):397-409. doi: 10.1016/0022-510x(79)90098-4.
A study of the distribution of phenylethanolamine-N-methyl-transferase (PNMT) activity in normal human brain is presented. After a preliminary dissection to separate brain tissue for formalin fixation and tissue designed for biochemical studies, the hemi-brain stem is cut in slices by hand and a cerebral hemisphere is cut on a cyromicrotome. "Punches" are made with an operating microscope. The dissection method was used to study the distribution of PNMT activity in 117 "punches" made on 21 slices obtained from 5 normal human brains. The caudo-rostral distribution of PNMT activity in C1 and C2 groups was found to be identical in each brain. The distribution of PNMT activity was found to be similar to that in the rat, but, in addition, important activity was found in the substantia nigra, internal pallidium and nucleus accumbens.
本文介绍了一项关于正常人脑中苯乙醇胺 -N-甲基转移酶（PNMT）活性分布的研究。在进行初步解剖以分离用于福尔马林固定的脑组织和用于生化研究的组织后，手动将半脑干切成薄片，并用低温切片机切割大脑半球。在手术显微镜下进行“打孔”操作。采用解剖方法研究了从5个正常人脑获取的21个切片上制作的117个“打孔”样本中PNMT活性的分布。发现C1和C2组中PNMT活性的尾 - 头分布在每个大脑中是相同的。PNMT活性的分布与大鼠相似，但此外，在黑质、苍白球内部和伏隔核中发现了重要活性。
