Lew J Y, Matsumoto Y, Pearson J, Goldstein M, Hökfelt T, Fuxe K
Brain Res. 1977 Jan 1;119(1):199-210. doi: 10.1016/0006-8993(77)90100-7.
The distribution of PNMT activity in various regions and nuclei of the rat, monkey and human brain was investigated. The distribution of PNMT activity in the rat brain correlates with the distribution of PNMT immunofluorescence. The PNMT activity in the primate brain is more widely distributed than in the rat brain. High and intermediate enzyme activity values were dound in the same regions of the primate brain as in the rat brain. Intermediate or low levels were also found in various other regions of the primate brain, e.g., basal ganglia, amygdala, septum, habenula. The brain PNMT has the same substrate specificity and similar kinetic properties as the adrenal enzyme. Immunotitration studies revealed cross-reactivity between the homologous adrenal and brain PNMT.
研究了大鼠、猴和人脑不同区域及神经核中苯乙醇胺-N-甲基转移酶（PNMT）活性的分布。大鼠脑中PNMT活性的分布与PNMT免疫荧光的分布相关。灵长类动物脑中PNMT的活性分布比大鼠脑中更为广泛。在灵长类动物脑与大鼠脑相同的区域发现了高和中等水平的酶活性值。在灵长类动物脑的其他各个区域，如基底神经节、杏仁核、隔区、缰核，也发现了中等或低水平的PNMT活性。脑PNMT与肾上腺酶具有相同的底物特异性和相似的动力学特性。免疫滴定研究揭示了同源的肾上腺和脑PNMT之间的交叉反应性。
