Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.

Suppr

超能文献

作者信息

Degkwitz E, Ullrich V, Staudinger H

出版信息

Hoppe Seylers Z Physiol Chem. 1969 May;350(5):547-53. doi: 10.1515/bchm2.1969.350.1.547.

DOI:10.1515/bchm2.1969.350.1.547

PMID:4389286

Abstract

摘要

相似文献

Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.

Hoppe Seylers Z Physiol Chem. 1969 May;350(5):547-53. doi: 10.1515/bchm2.1969.350.1.547.

Spectral studies of drug interaction with hepatic microsomal cytochrome.药物与肝微粒体细胞色素相互作用的光谱研究

Mol Pharmacol. 1967 Mar;3(2):113-23.

Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.

Biochem Biophys Res Commun. 1969 Aug 15;36(4):545-51. doi: 10.1016/0006-291x(69)90339-8.

Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.混合功能氧化酶与其底物的相互作用以及灌注大鼠肝脏中细胞色素P-450和吡啶核苷酸相关的氧化还原转变

Eur J Biochem. 1970 Sep;15(3):531-40. doi: 10.1111/j.1432-1033.1970.tb01037.x.

Possible role of P-450 in the oxidation of drugs in liver microsomes.P - 450在肝微粒体中药物氧化过程中的可能作用。

J Biochem. 1966 Jun;59(6):574-83. doi: 10.1093/oxfordjournals.jbchem.a128346.

Effect of phenobarbital and methylcholanthrene treatment on drug-induced difference spectrum of liver microsomes.

Jpn J Pharmacol. 1969 Mar;19(1):171-3. doi: 10.1254/jjp.19.171.

Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.药物与肝微粒体羟化酶的反应：其对药物作用的影响。

Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;259(2):98-116. doi: 10.1007/BF00537741.

EPR measurements of substrate interaction with cytochrome P-450.细胞色素P - 450与底物相互作用的电子顺磁共振测量

Biochem Biophys Res Commun. 1966 May 3;23(3):264-8. doi: 10.1016/0006-291x(66)90539-0.

The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations.氧化型细胞色素P-450和细胞色素b5在肝微粒体药物氧化中的作用。

Drug Metab Dispos. 1973 Jan-Feb;1(1):129-38.

Oxidation and glucuronidation of certain drugs in various subcellular fractions of rat liver: binding of desmethylimipramine and hexobarbital to cytochrome P-450 and oxidation and glucuronidation of desmethylimipramine, aminopyrine, p-nitrophenol and 1-naphthol.某些药物在大鼠肝脏不同亚细胞组分中的氧化和葡萄糖醛酸化作用：去甲丙咪嗪和己巴比妥与细胞色素P-450的结合以及去甲丙咪嗪、氨基比林、对硝基苯酚和1-萘酚的氧化和葡萄糖醛酸化作用

Acta Pharmacol Toxicol (Copenh). 1972;31(1):107-20. doi: 10.1111/j.1600-0773.1972.tb00703.x.

引用本文的文献

Hexobarbital-binding, hydroxylation and hexobarbital-dependent hydrogen peroxide production in hepatic microsomes of guinea pig, rat and rabbit.豚鼠、大鼠和家兔肝微粒体中己巴比妥结合、羟基化及己巴比妥依赖的过氧化氢生成

Naunyn Schmiedebergs Arch Pharmacol. 1980 Nov;314(2):201-10. doi: 10.1007/BF00504539.

A study of the possible metabolism of trichlorofluoromethane.三氯氟甲烷可能的代谢研究。

Biochem J. 1972 Nov;130(1):13P-14P. doi: 10.1042/bj1300013pb.

Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates.一系列光学活性N-甲基化巴比妥酸盐药理活性的立体化学依赖性。

Naunyn Schmiedebergs Arch Pharmacol. 1973;277(2):191-8. doi: 10.1007/BF00501159.

Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (-)-methylphenobarbital.大鼠肝微粒体中对（+）-和（-）-甲基苯巴比妥的结合及单加氧作用具有不同立体选择性的细胞色素P-450种类。

Naunyn Schmiedebergs Arch Pharmakol. 1971;270(1):41-55. doi: 10.1007/BF00997298.

Oxidation of barbiturates and the glucuronidation of 1-napthol in perfused rat liver and in microsomes.巴比妥类药物在灌注大鼠肝脏及微粒体中的氧化作用以及1-萘酚在其中的葡萄糖醛酸化作用。

Naunyn Schmiedebergs Arch Pharmacol. 1974;283(3):319-30. doi: 10.1007/BF00499191.

Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.苯巴比妥对小鼠小肠中药物单加氧酶活性的诱导作用

Naunyn Schmiedebergs Arch Pharmacol. 1973;276(1):89-98. doi: 10.1007/BF00500781.

Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin.利福平引起的己巴比妥异构体口服清除率的年龄依赖性立体选择性增加。

Br J Clin Pharmacol. 1991 Dec;32(6):735-9.

Effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines.

Naunyn Schmiedebergs Arch Pharmacol. 1976 Jul;294(1):91-7. doi: 10.1007/BF00692789.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验