异吲哚酮 N-曼尼希碱的抗菌和抗真菌活性
Antibacterial and antifungal activities of isatin N-Mannich bases.
作者信息
Kupinić M, Medić-Sarić M, Movrin M, Maysinger D
出版信息
J Pharm Sci. 1979 Apr;68(4):459-62. doi: 10.1002/jps.2600680417.
PMID:438969
Abstract
The antimicrobial and antifungal activities of 29 congeneric isatin N-Mannich bases were investigated by testing against standard test microorganisms and 21 pathogenic Gram-negative microorganisms. Considerable growth inhibition of Gram-negative bacteria and yeasts and slight inhibition of Gram-positive bacteria resulted when they were treated with the various N-Mannich bases of isatin and 5-nitroisatin, respectively.
摘要
通过对标准测试微生物和21种致病性革兰氏阴性微生物进行测试，研究了29种同属异吲哚酮N-曼尼希碱的抗菌和抗真菌活性。当分别用异吲哚酮和5-硝基异吲哚酮的各种N-曼尼希碱处理革兰氏阴性细菌和酵母时，观察到对它们有显著的生长抑制作用，而对革兰氏阳性细菌只有轻微的抑制作用。
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