大鼠纹状体中含多巴胺终末释放新合成的多巴胺。
Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat.
作者信息
Besson M J, Cheramy A, Feltz P, Glowinski J
出版信息
Proc Natl Acad Sci U S A. 1969 Mar;62(3):741-8. doi: 10.1073/pnas.62.3.741.
Abstract
The extraneuronal spontaneous efflux of (3)H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the (3)H amine in superfusates of isolated striatum of the rat previously incubated with (3)H-tyrosine. The (3)H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of (3)H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.
摘要
通过收集预先用³H - 酪氨酸孵育的大鼠离体纹状体灌流液中的³H胺，已在体外证明了多巴胺终末内源性合成的³H - 多巴胺的非神经元自发外流。新合成的³H - 多巴胺似乎优先被释放。此外，苯丙胺和一种单胺氧化酶抑制剂（卡托）显著增加了³H - 多巴胺的释放。在一些纹状体神经元中正常含有的物质（乙酰胆碱和5 - 羟色胺）也观察到了这种效应。
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