利血平、α-甲基酪氨酸和L-3,4-二羟基苯丙氨酸对脑酪氨酸转氨酶的作用。
The effects of reserpine, alpha-methyltyrosine, and L-3,4-dihydroxyphenylalanine on brain tyrosine transaminase.
作者信息
Gibb J W, Webb J G
出版信息
Proc Natl Acad Sci U S A. 1969 Jun;63(2):364-9. doi: 10.1073/pnas.63.2.364.
The effects of a variety of pharmacological and physiological manipulations on the activity of hepatic tyrosine transminase have been extensively investigated. Brain tyrosine transaminase, however, has received only limited attention. Since tyrosine transaminase may be important in the regulation of catecholamine biosynthesis in the brain, the effects of agents affecting catecholamine storage and synthesis on brain tyrosine transamination were investigated. Transamination in the 12,000 x g fraction was measured by a radioactive procedure. alpha-Methyltyrosine and reserpine, agents which deplete brain catecholamines, decreased tyrosine transaminase activity. Administration of the catecholamine precursor, L-3,4-dihydroxyphenylalanine to the reserpine-and alpha-methyltyrosine-treated rats elevated the tyrosine transaminase activity to normal. The possible implications of these findings in the regulation of the biosynthesis of the catecholamines are discussed.
多种药理和生理操作对肝酪氨酸转氨酶活性的影响已得到广泛研究。然而，脑酪氨酸转氨酶仅受到有限关注。由于酪氨酸转氨酶可能在脑内儿茶酚胺生物合成的调节中起重要作用，因此研究了影响儿茶酚胺储存和合成的药物对脑酪氨酸转氨酶活性的影响。通过放射性方法测定12,000×g组分中的转氨作用。α-甲基酪氨酸和利血平，这两种耗尽脑内儿茶酚胺的药物，降低了酪氨酸转氨酶活性。给利血平和α-甲基酪氨酸处理的大鼠施用儿茶酚胺前体L-3,4-二羟基苯丙氨酸可使酪氨酸转氨酶活性恢复正常。讨论了这些发现对儿茶酚胺生物合成调节的可能意义。
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